A rapid and simple method has been developed for chromatographic separation of the pharmacologically active components of some antihypertensive drugs. The active compounds — lisinopril, cilazapril, captopril, quinapril, and ramipril — were successfully separated on aminoplast layers with benzene-cyclohexane-methyl ethyl ketone, 15 + 10 + 15 (
), as mobile phase. The mechanism of retention and the correlation between lipophilicity and log
were both investigated.
M.B. Aleksić, D.G. Agbaba, R.M. Baošić, D.M. Milojković-Opsenica
, J. Serb. Chem. Soc.