High-performance thin-layer chromatography has been used to follow the synthesis of some quinoxalinone derivatives by biocatalysis in a one-pot reaction, as an alternative route to the poor Hinsberg reaction. The progress of the one-pot reactions can be followed by HPTLC without previous isolation of the different intermediates arising from them. Biocatalytic synthesis of quinoxalinone derivatives leads to an irreversible reaction which gives a single product of high purity and yields in excess of 90–95%.
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B.M. Fernández and M.I. Abasolo , J. Planar Chromatogr. 3 (1990) 20–23.
Abasolo M.I. , '' (1990 ) 3 J. Planar Chromatogr. : 20 -23.
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H. Hinsberg , Liebigs Ann. Chem. 237 (1887) 368–373.
Hinsberg H. , '' (1887 ) 237 Liebigs Ann. Chem. : 368 -373.
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K.M. Varshney , J. Planar Chromatogr. 15 (2002) 46–49.
Varshney K.M. , '' (2002 ) 15 J. Planar Chromatogr. : 46 -49.
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