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  • 1 Gedeon Richter Ltd Central Analytical Laboratories H-1475 Budapest 10 P.O.B. 27 Hungary
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An OPLC purity test suitable for routine analysis of norethisterone bulk drug substance and in tablets has been developed. Separation was performed on a fine-particle silica gel adsorbent layer by continuous development with n -hexane and butyl acetate-chloroform, 85 + 15 ( v/v ), as mobile phases. Visualization of the chromatogram by use of sulfuric acid enables detection of less than 0.05% of possible impurities by use of long-wave UV illumination. The selectivity and efficiency of this OPLC method were compared with those of the pharmacopeial TLC methods and those of HPLC method.

  • B. Bagócsi, D. Fábián, A. Laukó, M. Mezei, S. Mahó, Z. Végh , and K. Ferenczi-Fodor , J. Planar Chromatogr. 15 (2002) 252–257.

    Ferenczi-Fodor K. , '' (2002 ) 15 J. Planar Chromatogr. : 252 -257.

  • European Pharmacopoeia, 4th edn, Council of Europe, Strasbourg, 2001 p. 1646.

  • The United States Pharmacopoeia 26th edn, USP Convention, Rockville, MD, 2002, p. 1328.

  • The Japanese Pharmacopoeia 14th edn, Soc. Jap. Pharm., Tokyo, 2001, p. 650.

  • E. Tyihák and E. Mincsovics , Overpressured Layer Chromatography (Optimum Performance Laminar Chromatography) (OPLC). In: Sz. Nyiredy (Ed.) Planar Chromatography — A Retrospective View for the Third Millennium, Springer, Budapest, 2001, pp. 137–176.

    Mincsovics E. , '', in Planar Chromatography — A Retrospective View for the Third Millennium , (2001 ) -.

  • B. Bagócsi, G. Rippel, Z. Végh, S. Mahó , and K. Ferenczi-Fodor , in: Sz. Nyiredy (Ed.) Proc. Int. Symp. Planar Separations — Planar Chromatography 2000, Lillafüred, Hungary, June 2000, Research Institute Medicinal Plants, Budakalász, Hungary, pp. 151–156.

    Ferenczi-Fodor K. , '', in Proc. Int. Symp. Planar Separations — Planar Chromatography 2000, Lillafüred, Hungary , (2000 ) -.

  • B. Bagócsi, D. Fábián, M. Mezei, S. Mahó, Z. Végh , and K. Ferenczi-Fodor , 11th Int. Symp. Pharmaceutical and Biomedical Analysis, May 14–18, 2000, Basel, Switzerland. Abstracts book P 019.

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  • E. Reich (Muttenz, Switzerland)
  • B. Renger (Radolfzell, Germany)
  • I. Vovk (Ljubljana, Slovenia)

 

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  • U. A. TH. BRINKMAN (Amsterdam, The Netherlands)
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  • W. DAMMERTZ (Kressbronn, Germany)
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  • E. MINCSOVICS (Budapest, Hungary)
  • D. NUROK (Indianapolis, IN, USA)
  • B. RENGER (Radolfzell, Germany)
  • J. K. RÓŻYŁO (Lublin, Poland)
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Address: P.O. Box 245. H-1519 Budapest, Hungary
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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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