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  • 1 Semmelweis University Department of Pharmacology and Pharmacotherapy Nagyvárad tér 4 H-1089 Budapest Hungary
  • 2 Semmelweis University Budapest Central Isotope Laboratory Nagyvárad tér 4 1089 Budapest Hungary
  • 3 EGIS Pharmaceuticals Co. Ltd Department of Pharmacokinetics Keresztúri út 30-38 H-1106 Budapest Hungary
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Thin-layer chromatography has been used to monitor formaldehyde production during in-vivo metabolism of (−)-deprenyl. Formaldehyde was reacted with dimedone to yield its dimedone adduct, formaldemedone. Determination of 14 C-labeled formaldemedone was performed by planar displacement chromatography. The separated bands were detected either by digital autoradiography or on X-ray film after contact autoradiography. Two-dimensional separations have improved the evaluation.

  • H. Kalász, M. Báthori, I. Hollósi, G. Jakab, É. Szökő, K. Magyar , and S. Fürst , in: K. Magyar and E.S. Vizi (Eds) Milestones in monoamine oxidase research: discovery of (−)-deprenyl, Medicina, Budapest, 2000, pp. 81–94.

    Fürst S. , '', in Milestones in monoamine oxidase research: discovery of (−)-deprenyl , (2000 ) -.

  • H. Kalász, L. Kerecsen, J. Knoll , and J. Pucsok , J. Chromatogr. 499 (1990) 589–599.

    Pucsok J. , '' (1990 ) 499 J. Chromatogr. : 589 -599.

  • T. Csermely, H. Kalász, K. Rischák, M. Báthori, Zs. Tarjányi , and S. Fürst , J. Planar Chromatogr. 11 (1998) 247–253.

    Fürst S. , '' (1998 ) 11 J. Planar Chromatogr. : 247 -253.

  • H. Kalász , J. High Resol. Chromatogr. Chromatogr. Commun. 6 (1983) 49–50.

    Kalász H. , '' (1983 ) 6 J. High Resol. Chromatogr. Chromatogr. Commun. : 49 -50.

  • H. Kalász, M. Báthori , and E. Tyihák , Acta Biol. Hung. 49 (1998) 229–344.

    Tyihák E. , '' (1998 ) 49 Acta Biol. Hung. : 229 -344.

  • L.Z. Benet, D.L. Kroetz , and L.B. Sheiner , in: J.G. Hardman, L.E. Libird, P.B. Matinoll , and R.W. Ruddon (Eds) Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 9th edn, McGraw-Hill, New York, 1995, p. 13.

    Sheiner L.B. , '', in Goodman and Gilman’s The Pharmacological Basis of Therapeutics , (1995 ) -.

  • M.A. Correia , in: B.G. Katzung (Ed.), Basic and Clinical Pharmacology, 7th edn, Appleton and Lange, Stamford, CT, 1998, p. 53.

    Correia M.A. , '', in Basic and Clinical Pharmacology , (1998 ) -.

  • T.K. Różyło , Biomed. Chromatogr. 12 (1998) 267–270.

    Różyło T.K. , '' (1998 ) 12 Biomed. Chromatogr. : 267 -270.

  • E. Tyihák, L. Albert, Zs. Németh, Gy. Kátay, Zs. Király-Véghely , and B. Szende , Acta Biol. Hung. 49 (1998) 209–218.

    Szende B. , '' (1998 ) 49 Acta Biol. Hung. : 209 -218.

  • Y. Deng and P.H. Yu , J. Chromatogr. Sci. 37 (1999) 317–322.

    Yu P.H. , '' (1999 ) 37 J. Chromatogr. Sci. : 317 -322.

  • I. Klebovich, J. Szúnyog , and I. Hazai , J. Planar Chromatogr. 10 (1997) 399–405.

    Hazai I. , '' (1997 ) 10 J. Planar Chromatogr. : 399 -405.

  • I. Klebovich , in Sz. Nyiredy (Ed.) Planar Chromatography — A Retrospective View for the Third Millennium, Springer, Budapest, 2001, pp. 293–311.

    Klebovich I. , '', in Planar Chromatography — A Retrospective View for the Third Millennium , (2001 ) -.

  • I. Hazai and I. Klebovich , in: J. Sherma and B. Fried (Eds) Handbook of Thin-Layer Chromatography, 3rd edn, Marcel Dekker, New York, 2003, pp. 339–360.

    Klebovich I. , '', in Handbook of Thin-Layer Chromatography , (2003 ) -.

  • H.S. Shin , Drug Metab. Disp. 25 (1997) 657–662.

    Shin H.S. , '' (1997 ) 25 Drug Metab. Disp. : 657 -662.

  • J. Lengyel, K. Magyar, I. Hollósi, T. Bartók, M. Báthori, H. Kalász , and S. Fürst , J. Chromatogr. 762 (1997) 321–326.

    Fürst S. , '' (1997 ) 762 J. Chromatogr. : 321 -326.

  • H. Kalász, T. Bartók, R. Komoróczy, É. Szökő, D. Haberle, J.P. Kiss, E. Hennings, K. Magyar , and S. Fürst , Curr. Med. Chem. 6 (1999) 215–222.

    Fürst S. , '' (1999 ) 6 Curr. Med. Chem. : 215 -222.

  • J. Lengyel, H. Kalász, T. Szarvas, Cs. Peltz , and A. Szarkane-Bolehovszky , J. Chromatogr. Sci. 41 (2003) 177–181.

    Szarkane-Bolehovszky A. , '' (2003 ) 41 J. Chromatogr. Sci. : 177 -181.

  • H. Kalász, T. Szarvas, A. Szarkáné-Bolehovszky , and J. Lengyel , J. Liq. Chromatogr. Related Technol. 25 (2002) 1589–1598.

    Lengyel J. , '' (2002 ) 25 J. Liq. Chromatogr. Related Technol. : 1589 -1598.

  • M. Katagi, M. Tatsuno, A. Miki, M. Nishikawa, K. Nakajima and H. Tsuchihashi , J. Chromatogr. B. 759 (2001) 125–133.

    Tsuchihashi H. , '' (2001 ) 759 J. Chromatogr. B. : 125 -133.

  • Zs. Tarjányi, H. Kalász, Gy. Szebeni, I. Hollósi, M. Báthori , and Zs. Fürst , J. Pharm. Biomed. Anal. 17 (1998) 725–731.

    Fürst Zs. , '' (1998 ) 17 J. Pharm. Biomed. Anal. : 725 -731.

  • T. Csermely, H. Kalász, K. Rischák, M. Báthori, Zs. Tarjányi , and S. Fürst , J. Planar Chromatogr. 11 (1998) 247–253.

    Fürst S. , '' (1998 ) 11 J. Planar Chromatogr. : 247 -253.

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