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  • 1 University of Belgrade Institute of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy Vojvode Stepe 450 P.O. Box 146 11000 Belgrade Serbia and Montenegro
  • 2 University of Belgrade Institute of Analytical Chemistry, Faculty of Pharmacy Vojvode Stepe 450 P.O. Box 146 11000 Belgrade Serbia and Montenegro
  • 3 Zdravlje — Pharmaceutical and Chemical Industry Quality Control Sector 16000 Leskovac Serbia and Montenegro
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A method has been developed for separation of omeprazole and pantoprazole, and their impurities omeprazole sulfone and N -methylpantoprazole, by HPTLC. The mobile phase chloroform-2-propanol-25% ammonia-acetonitrile, 10.8 + 1.2 + 0.3 + 4 ( v/v ), enables good resolution of large excesses of the drugs from the possible impurities. Regression coefficients ( r > 0.998), recovery (90.7–120.0%), and detection limit (0.025–0.05%) were validated and found to be satisfactory. The methods is convenient for quantitative analysis and purity control of the compounds.

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