JPC - Journal of Planar Chromatography - Modern TLC
Volume/Issue:
Volume 17: Issue 4
ChemScreen: Planar synthesis, separation and screening of antioxidants
Authors:
Lorenzo Williams SINTEF Applied Chemistry P.O. Box 124 Blindern N-314 Oslo Norway

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Rigmor Sjøvik Norwegian University of Science and Technology Department of Chemistry NO-7491 Trondheim Norway

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Mette Falck-Pedersen SINTEF Applied Chemistry P.O. Box 124 Blindern N-314 Oslo Norway

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Pages:
244–249
Online Publication Date:
08 Mar 2007
Publication Date:
01 Aug 2004
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jpc.17.2004.4.1
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The method described herein is a very powerful tool for rapid synthesis, separation, and screening of combinatorial libraries on planar media. Thirty compounds were synthesized and separated affording discrete chemical entities, including by-products, which were screened for antioxidant activity. The whole process from synthesis to screening was performed manually and took between 30 and 60 min after optimization of the reaction.A series of coumarin derivatives was synthesized by Knoevenagel condensation of salicylaldehyde derivatives with active methylene species, assisted by microwave irradiation, using a TLC plate as planar support. Elution of the reaction mixtures afforded discrete coumarin products which were screened directly on the plate for antioxidant activity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) test radical.Active compounds were scaled-up and re-screened for potency in comparison with Irgafos 38, a known antioxidant commonly incorporated as an additive in plastics. The potency of all the active species was of the same order of magnitude as that of Irgafos 38. The lower limit of activity of 8-hydroxy-2-oxo-2 H -chromene-3-carboxylic acid ethyl ester was 600 ng compared with 700 ng for Irgafos 38.

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Cover JPC - Journal of Planar Chromatography - Modern TLC
JPC - Journal of Planar Chromatography - Modern TLC
Print ISSN:
0933-4173
Online ISSN:
1789-0993

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 6
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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