JPC - Journal of Planar Chromatography - Modern TLC
Volume/Issue:
Volume 17: Issue 4
Study of lipophilicity and application of selected topological indexes in QSAR analysis of nicotinic acid derivatives. Part I
Author:
Alina Pyka Silesian Academy of Medicine Department of Analytical Chemistry, Faculty of Pharmacy 4, Jagiellonska Street PL-41200 Sosnowiec Poland

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Pages:
275–279
Online Publication Date:
08 Mar 2007
Publication Date:
01 Aug 2004
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jpc.17.2004.4.6
Restricted access

Selected nicotinic acid derivatives have been chromatographed on RP-HPTLC plates with methanol-water in different volume proportions as mobile phases. Linear relationships were obtained between RM values of nicotinic acid derivatives and the volume fraction of methanol in the mobile phase. The retention values RM were extrapolated to zero methanol content and the lipophilicity values RM0 obtained were compared with measured (log Pexp ) partition coefficients and values ( A log P s, IA log P , C log P , log PKowin , and x log P ) calculated by use of five different software products. A linear relationship was obtained between RM0 and the slope, S , of the chromatography equation. The most significant correlation was found between the RM0 and A log P s values. For the nicotinic acid derivatives RM0 was a slightly better measure of lipophilicity than ϕ0 . Chromatographic RM0 values can be use as a measure of the lipophilicity of the nicotinic acid derivatives investigated. Satisfactory linear correlation was obtained between RM0 and some topological indexes ( oχv , 1χv , 1B , 2B , ISA , and Ī SA ).

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Cover JPC - Journal of Planar Chromatography - Modern TLC
JPC - Journal of Planar Chromatography - Modern TLC
Print ISSN:
0933-4173
Online ISSN:
1789-0993

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 6
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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