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Jadranka Odović University of Belgrade Faculty of Pharmacy P.O. Box 146 11001 Belgrade Serbia and Montenegro

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Biljana Stojimirović University of Belgrade School of Medicine 11001 Belgrade Serbia and Montenegro

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Mirjana Aleksić University of Belgrade Faculty of Pharmacy P.O. Box 146 11001 Belgrade Serbia and Montenegro

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Dušanka Milojković-Opsenica University of Belgrade Faculty of Chemistry P.O. Box 158 11001 Belgrade Serbia and Montenegro

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Živoslav Tešić University of Belgrade Faculty of Chemistry P.O. Box 158 11001 Belgrade Serbia and Montenegro

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The behavior of five ACE inhibitors and their active degradation products in salting-out thin-layer chromatography (SO TLC) has been examined on silica gel, cellulose, and polyacrylonitrile (PAN) with aqueous ammonium sulfate solutions of different concentration as mobile phases. It was found that increasing the concentration of the salt in the mobile phase led to increased RM values for all the substances. Linear relationships were established between salt concentration and RM values and regression data of the plots obtained were used to determine the lipophilicity RM0 and C0 . Lipophilicity determined in this way was correlated with calculated log P values. For comparison of these results with chromatographic behavior in conventional RP TLC, the examined substances were subjected to thin-layer chromatography on RP-18 silica gel with methanol-water mobile phases.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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