JPC - Journal of Planar Chromatography - Modern TLC
Volume/Issue:
Volume 18: Issue 105
Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography
Authors:
Jelena Veličković University of Belgrade Faculty of Chemistry P.O. Box 158 11001 Belgrade Serbia and Montenegro

Search for other papers by Jelena Veličković in
Current site
Google Scholar
PubMed Close
,
Živoslav Tešić University of Belgrade Faculty of Chemistry P.O. Box 158 11001 Belgrade Serbia and Montenegro

Search for other papers by Živoslav Tešić in
Current site
Google Scholar
PubMed Close
, and
Dušanka Milojković-Opsenica University of Belgrade Faculty of Chemistry P.O. Box 158 11001 Belgrade Serbia and Montenegro

Search for other papers by Dušanka Milojković-Opsenica in
Current site
Google Scholar
PubMed Close
Pages:
358–363
Online Publication Date:
17 Mar 2007
Publication Date:
01 Oct 2005
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jpc.18.2005.5.4
Keywords:
Lipophilicity; RP-18 silica; 1-Arylpiperazines
Restricted access

The lipophilic character of some biologically active 1-arylpiperazines has been studied. A reversed-phase planar chromatographic procedure was established for determination of log PO-W values ( n -octanol-water partition coefficients) for the compounds. The compounds were chromatographed with five so-called ‘standards’ on RP-18 silica plates with methanol-water and dioxane-water binary systems as mobile phases. n -Octanol-water partition coefficients for five standard compounds determined experimentally by use of the shake-flask method were used to obtain the log PO-W values of the 1-arylpiperazines investigated. Experimentally established log PO-W values were compared with log P values calculated by use of five different software packages.

  • T. Fujita, J. Iwasa , and C. Hansch , J. Am. Chem. Soc. 86 (1964) 5175–5180.

    Hansch C. , '' (1964 ) 86 J. Am. Chem. Soc. : 5175 -5180 .

  • C. Altomare, R.-S. Tsai, N. Tayar, B. Testa, A. Carroti, S. Cellamare , and P.G. de Benedetti , J. Pharm. Pharmacol. 43 (1991) 191–197.

    Benedetti P.G. , '' (1991 ) 43 J. Pharm. Pharmacol. : 191 -197 .

  • R. Kaliszan, A. Nasal , and M.J. Markuszewski , Anal. Bioanal. Chem. 377 (2003) 803–811.

    Markuszewski M.J. , '' (2003 ) 377 Anal. Bioanal. Chem. : 803 -811 .

  • K. Valkó , J. Chromatogr. A 1037 (2004) 299–310.

    Valkó K. , '' (2004 ) 1037 J. Chromatogr. A : 299 -310 .

  • T. Hartmann and J. Schmitt , DDT: Technologies 1 (4) (2004) 431–439.

    Schmitt J. , '' (2004 ) 1 DDT: Technologies : 431 -439 .

  • A. Pyka and M. Miszczyk , Chromatographia 61 (2005) 37–42.

    Miszczyk M. , '' (2005 ) 61 Chromatographia : 37 -42 .

  • I.V. Tetko and V.Yu Tanchuk , Virtual Computational Chemistry Laboratory, VCC-lab 2002, http://146.107.217.178/servlets/vcclab?action=alogps

  • G.E. Granero, M.M. de Bertorello , and M.C. Brińón , J. Liq. Chromatogr. Related Technol. 22 (2) (1999) 229–240.

    Brińón M.C. , '' (1999 ) 22 J. Liq. Chromatogr. Related Technol. : 229 -240 .

  • I.V. Tetko and V.Yu Tanchuk , J. Chem. Inf. Comput. Sci. 42 (2002) 1136–1145.

    Tanchuk V. , '' (2002 ) 42 J. Chem. Inf. Comput. Sci. : 1136 -1145 .

  • M. Parham, L. Hall , and L. Kier , Accurate Prediction of log P Using E-state Indices with Neutral Network Analysis. ACS Meeting, Washington, DC, 12 April 2002; available as Microsoft Power Point file at http://www.logp.com/

  • C. Hanch and A.J. Leo , Substituent Constants for Correlation Analysis in Chemistry and Biology, Wiley, New York, 1979.

    Leo A.J. , '', in Substituent Constants for Correlation Analysis in Chemistry and Biology , (1979 ) -.

  • J. Chou and P.C. Jurs , Chem. Inform. Comput. Sci. 19 (1979) 172–178.

    Jurs P.C. , '' (1979 ) 19 Chem. Inform. Comput. Sci. : 172 -178 .

  • W. Meylan and P. Howard , J. Pharm. Sci. 84 (1995) 83–92.

    Howard P. , '' (1995 ) 84 J. Pharm. Sci. : 83 -92 .

  • R. Wang, Y. Fu , and L. Lai , J. Chem. Inf. Comput. Sci. 37 (1997) 615–621.

    Lai L. , '' (1997 ) 37 J. Chem. Inf. Comput. Sci. : 615 -621 .

  • J. Veličković, D. Andrić, G. Roglić, Ž. Tešić , and D. Milojković-Opsenica , J. Planar Chromatogr. 17 (2004) 255–260.

    Milojković-Opsenica D. , '' (2004 ) 17 J. Planar Chromatogr. : 255 -260 .
  • Collapse
  • Expand
Cover JPC - Journal of Planar Chromatography - Modern TLC
JPC - Journal of Planar Chromatography - Modern TLC
Print ISSN:
0933-4173
Online ISSN:
1789-0993

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 6
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Aug 2024 13 0 0
Sep 2024 19 0 0
Oct 2024 39 0 0
Nov 2024 19 0 0
Dec 2024 31 0 0
Jan 2025 10 0 0
Feb 2025 0 0 0