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  • 1 Medical University of Lublin Department of Inorganic and Analytical Chemistry Staszica 6 20-081 Lublin Poland
  • | 2 Medical University of Lublin Department of Organic Chemistry Staszica 6 20-081 Lublin Poland
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The reversed-phase thin layer chromatographic retention behavior of some new derivatives of 1,2,4-triazole and thiosemicarbazide has been determined. Linear relationships were established between the retention ( RM ) of each solute and the volume fraction of organic modifier (methanol or acetonitrile) in organic-aqueous mobile phases. This enabled determination of chromatographic lipophilicity data — RMW values by extrapolation, ϕ0 by interpolation for each organic modifier, and S denoting the slope of the linear dependences. Moderate correlation was established between chromatographic lipophilicity and log PG calculated by use of Chem Plus software. Experimental lipophilicity log PTLC was also determined for each solute by the use of a special calibration plot prepared by use of selected sulfonamide standards for the two mobile phase systems used in this study. The effect of different mobile-phase modifiers on experimentally obtained lipophilicity was studied and compared.

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