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Nayana Kapadia L.M. College of Pharmacy Department of Pharmacognosy Navarangpura, Ahmedabad (Gujarat) 380009 India

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Niyati Acharya TPS. Gandhinagar Type: 1-4/1, GEB Colony Gandhinagar (Gujarat) 382041 India

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Sanjiv Acharya TPS. Gandhinagar Type: 1-4/1, GEB Colony Gandhinagar (Gujarat) 382041 India

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Mamta Shah L.M. College of Pharmacy Department of Pharmacognosy Navarangpura, Ahmedabad (Gujarat) 380009 India

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Convolvulus pluricaulis is a highly valued rasayana drug of the Ayurvedic system of medicine. It is one of the four drugs ( Convolvulus pluricaulis, Evolvulus alsinoides, Clitoria ternatea , and Canscora decussata ) described in Ayurveda as Shankhpushpi. Because C. pluricaulis is described and used as Shankhpushpi by most practitioners, the objective of this study was to develop an HPTLC method for generation of a distinct chemical profile of Shankhpushpi and for quantification of scopoletin in C. pluricaulis and in commercial formulations containing the plant. Because scopoletin is one of the major coumarins in C. pluricaulis , it was used as a chemical marker. Chromatography on silica gel, with toluene-ether, 1 + 1, saturated with 10% glacial acetic acid, as mobile phase enabled good resolution of scopoletin without interference from other compounds present in Shankhpushpi. Scopoletin was resolved at RF 0.31 as a blue fluorescent spot when scanned at λ =366 nm. The study was extended to the analysis of commercial samples and formulations containing Shankhpushpi. Scopoletin was found to be present in almost all the commercial samples and formulations. Three other coumarins of RF 0.47, 0.55, and 0.63 were present in some of the samples. The HPTLC results were confirmed by results from UV spectroscopic scanning of the samples at λ = 366 nm. The method was validated for linearity (400–1200 ng/spot), correlation coefficient (0.9881), accuracy (recovery = 98.3%), precision (or CV, %; intraday 1.5–3.3%, interday 3.5–5.5%), limit of detection (50 ng/spot), and limit of quantification (100 ng/spot). The method is simple, sensitive, and precise and can be used for routine quality-control testing of C. pluricaulis and its commercial formulations.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
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Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
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H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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