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  • 1 Semmelweis University Department of Pharmaceutics Hőgyes Endre Street 7 1092 Budapest Hungary
  • | 2 EGIS Pharmaceuticals PLC Keresztúri Street 30-38 1106 Budapest Hungary
  • | 3 OPLC-NIT Ltd. Andor Street 60 1119 Budapest Hungary
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We report a new combination of overpressured-layer chromatography (OPLC) with near-infrared (NIR) spectroscopy for pharmaceutical analysis. Different pharmaceutical preparations containing caffeine, paracetamol, and acetylsalicylic acid as model compounds were separated by OPLC. The band density in the solid phase after OPLC was suitable for study of the separated components directly on the layer by NIR spectroscopy.We have demonstrated the applicability of rapid OPLC separation combined with UV densitometry and NIR spectroscopy for both qualitative and quantitative analysis. This OPLC-UV-NIR technique is thus suitable for rapid, nondestructive investigation of multicomponent pharmaceutical preparations and enables a different type of pharmaceutical analysis, e.g. starting-material tests, in-process control, end-product control, stability testing, etc. Another benefit of this newly developed combination of rapid off-line techniques is the possibility of simultaneous collection of qualitative and quantitative chromatographic and spectral information.

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