View More View Less
  • 1 Silesian Academy of Medicine Department of Analytical Chemistry, Faculty of Pharmacy 4 Jagiellońska Street 41-200 Sosnowiec Poland
  • | 2 Silesian University Institute of Chemistry Katowice Poland
Restricted access

Selected cortisone derivatives (corticosterone acetate, 11-dehydrocorticosterone acetate, corticosterone, 11-dehydrocorticosterone, allo-dihydrocortisone, hydrocortisone, and cortisone) have been separated by reversed-phase thin-layer chromatography and reversed-phase high-performance liquid chromatography. Experimental partition coefficients (log Pexp ) of the derivatives were determined for the n -octanol-water system. Chromatographic data ( RF , RM , tR , and log k ) were correlated with experimental (log Pexp ) and with theoretical n -octanol-water partition coefficients ( A log PS , IA log P , log PKowwin , x log P , C log P , mi log P , log PRekker ) and with the hydrophilic-lipophilic balance ( HLB ) of the compounds. It was found that corticosterone acetate should have the highest lipophilicity whereas cortisone should have the lowest. It was found that the chromatographic retention data ( RF , RM , tR , and log k ) correlated best with mi log P and x log P . Because the experimental values (log Pexp ) of all the cortisone derivatives investigated were closest to mi log P values ( r = 0.9915) we conclude that mi log P is the best theoretical partition coefficient for evaluation of the lipophilicity of these cortisone derivatives.

  • J. Sherma , Steroids. In: J. Sherma and B. Fried (Eds) Handbook of Thin-Layer Chromatography, Marcel Dekker, New York, 2003, pp. 913–933.

    Sherma J. , '', in Handbook of Thin-Layer Chromatography , (2003 ) -.

  • A. Franchini, E. Marchesini , and E. Ottaviani , Histol. Histopathol. 10 (2004) 693–699.

    Ottaviani E. , '' (2004 ) 10 Histol. Histopathol. : 693 -699.

  • Y. Ronquist-Nii and P.O. Edlund , J. Pharm. Biomed. Anal. 37 (2005) 341–350.

    Edlund P.O. , '' (2005 ) 37 J. Pharm. Biomed. Anal. : 341 -350.

  • M. Ando, I.S. Park, N. Wada , and Y. Takahashi , Ann. Thorac. Surg. 80 (2005) 1672–1678.

    Takahashi Y. , '' (2005 ) 80 Ann. Thorac. Surg. : 1672 -1678.

  • D. Keh, S. Goodman , and C.L. Sprung , Crit. Care Med. 25 (2004) 713–719.

    Sprung C.L. , '' (2004 ) 25 Crit. Care Med. : 713 -719.

  • A.W. Nichols , Clin. J. Sport Med. 15 (2005) E370.

    Nichols A.W. , '' (2005 ) 15 Clin. J. Sport Med. : E370 -.

  • Steroids: anabolic vs. corticosteroids — difference between anabolic and corticosteroids. http://arthritis.about.com/od/steroids/f/anabolicsteroid.htm

  • H. Kubinyi , The quantitative analysis of structure-activity relationships. In: M.E. Wolff (Ed) Burger’s Medicinal Chemistry and Drug Discovery, 5th edn, Vol. 1, Principles and Practice, John Wiley and Sons, 1995, pp. 497–571.

  • K. Jozwiak, H. Szumiło , and E. Soczewiński , Wiad. Chem. 55 (2001) 1047–1074 (in Polish).

    Soczewiński E. , '' (2001 ) 55 Wiad. Chem. : 1047 -1074.

  • R.F. Rekker and R. Mannhold , Calculation of Drug Lipophilicity, VCH, Weinheim, 1992.

    Mannhold R. , '', in Calculation of Drug Lipophilicity , (1992 ) -.

  • R.F. Rekker , The Hydrophobic Fragmental Constant, Elsevier, Amsterdam, The Netherlands, 1977

    Rekker R.F. , '', in The Hydrophobic Fragmental Constant , (1977 ) -.

  • R. Kaliszan , Quantitative Structure-Chromatographic Retention Relationships, Wiley Interscience, New York, 1987, pp. 232–295.

    Kaliszan R. , '', in Quantitative Structure-Chromatographic Retention Relationships , (1987 ) -.

  • N.U. Perisic-Janjic, B. Lucic, N.J. Janjic , and D. Agbaba , J. Planar Chromatogr. 16 (2003) 347–350.

    Agbaba D. , '' (2003 ) 16 J. Planar Chromatogr. : 347 -350.

  • A. Pyka and W. Klimczok , J. Planar Chromatogr. 18 (2005) 300–304.

    Klimczok W. , '' (2005 ) 18 J. Planar Chromatogr. : 300 -304.

  • T.B. Tosti, K. Drijevic, D.M. Milojojkovic-Opsenica , and Z.Lj. Tesić , J. Planar Chromatogr. 18 (2005) 415–418.

    Tesić Z.Lj. , '' (2005 ) 18 J. Planar Chromatogr. : 415 -418.

  • T. Djakovic-Sekulic, C. Sarbu , and N.U. Perisic-Janjic , J. Planar Chromatogr. 18 (2005) 432–436.

    Perisic-Janjic N.U. , '' (2005 ) 18 J. Planar Chromatogr. : 432 -436.

  • A. Pyka and M. Miszczyk , Chromatographia 61 (2005) 37–42.

    Miszczyk M. , '' (2005 ) 61 Chromatographia : 37 -42.

  • A. Leo, P.Y.C. Jow, C. Silipo , and C. Hansch , J. Med. Chem. 18 (1975) 865–868.

    Hansch C. , '' (1975 ) 18 J. Med. Chem. : 865 -868.

  • C. Hansch and A.J. Leo , Substituent Constants for Correlation Analysis in Chemistry and Biology, John Wiley, New York, 1979.

    Leo A.J. , '', in Substituent Constants for Correlation Analysis in Chemistry and Biology , (1979 ) -.

  • J. Chou and P.C. Jurs , Chem. Inform. Comput. Sci. 19 (1979) 172–178.

    Jurs P.C. , '' (1979 ) 19 Chem. Inform. Comput. Sci. : 172 -178.

  • W.M. Meylan and P.H. Howard , J. Pharm. Sci. 84 (1995) 83–92.

    Howard P.H. , '' (1995 ) 84 J. Pharm. Sci. : 83 -92.

  • I.V. Tetko, V. Yu. Tanchuk , and L. Lai , J. Chem. Inf. Comput. Sci. 42 (2002) 1136–1145.

    Lai L. , '' (2002 ) 42 J. Chem. Inf. Comput. Sci. : 1136 -1145.

  • R. Wang, Y. Fu , and L. Lai , J. Chem. Inf. Comput. Sci. 37 (1997) 615–621.

    Lai L. , '' (1997 ) 37 J. Chem. Inf. Comput. Sci. : 615 -621.

  • R. Mannhold and K. Dross , Quant. Struct.-Act. Relat. 15 (1996) 403–409.

    Dross K. , '' (1996 ) 15 Quant. Struct.-Act. Relat. : 403 -409.

  • I.V. Tetko and V. Yu. Tanchuk , Virtual Computational Chemistry Laboratory, http://146.107.217.178/servlets/vcclab?action=AlogPS (data of 27 March 2006)

  • Interactive analysis log P predictors. www.logp.com. (data of 27 March 2006).

  • miLogP2.2, Molinspiration property calculation service FAQ, http://www.molinspiration.com (data of 27 march 2006)

  • ClogP 4.0, http://www.biobyte.com/bb/prod/clogp40.html (data of 27 march 2006)

  • J. Śliwiok, A. Podgorny, A. Siwek , and B. Witkowska , J. Planar Chromatogr. 3 (1990) 410–412.

    Witkowska B. , '' (1990 ) 3 J. Planar Chromatogr. : 410 -412.

  • A. Pyka , J. Liq. Chromatogr. Related Technol. 24 (2001) 453–460.

    Pyka A. , '' (2001 ) 24 J. Liq. Chromatogr. Related Technol. : 453 -460.

  • A. Pyka and M. Babuśka , J. Liq. Chromatogr. Related Technol. 29 (2006) 1891–1903.

    Babuśka M. , '' (2006 ) 29 J. Liq. Chromatogr. Related Technol. : 1891 -1903.

  • S. Nakai and E. Li-Chan , Hydrophobic Interactions in Food Systems, CRC Press, Boca Raton, Florida, 1988.

    Li-Chan E. , '', in Hydrophobic Interactions in Food Systems , (1988 ) -.

For Submission Guideline click HERE

Manuscript Submission: JPC Manuscript Submission

Senior editors

Editor(s)-in-Chief: B. Spangenberg

Managing Editor: Kakuk Ágnes

Editorial Board

  • T.H. Dzido (Lublin, Poland)
  • Á. M. Móricz (Budapest, Hungary)
  • C.F. Poole (Detroit, MI, USA)
  • E. Reich (Muttenz, Switzerland)
  • B. Renger (Radolfzell, Germany)
  • I. Vovk (Ljubljana, Slovenia)

 

Advisory Board

  • E. BODOKI (Cluj-Napoca, Romania)
  • U. A. TH. BRINKMAN (Amsterdam, The Netherlands)
  • I. CHOMA (Lublin, Poland)
  • V. COMAN (Cluj-Napoca, Romania)
  • W. DAMMERTZ (Kressbronn, Germany)
  • K. FERENCZI-FODOR (Budapest, Hungary)
  • G. INDRAYANTO (Surabaya, Indonesia)
  • R. E. KAISER (Bad Dürkheim, Germany)
  • I. KLEBOVICH (Budapest, Hungary)
  • T. KOWALSKA (Katowice, Poland)
  • L. LEPRI (Florence, Italy)
  • E. MINCSOVICS (Budapest, Hungary)
  • D. NUROK (Indianapolis, IN, USA)
  • B. RENGER (Radolfzell, Germany)
  • J. K. RÓŻYŁO (Lublin, Poland)
  • J. SHERMA (Easton, PA, USA)
  • M. WAKSMUNDZKA-HAJNOS (Lublin, Poland)
  • D. WEDGE (Mississippi, USA)

A. Kakuk - Managing Editor, Akadémiai Kiadó
Address: P.O. Box 245. H-1519 Budapest, Hungary
Fax: +36 1 464 82 95
E-mail: jpc@akkrt.hu

Indexing and Abstracting Services:

  • Science Citation Index
  • Sci Search Research Alert
  • Chemistry Citation Index and Current Content/Physical
  • Chemical and Earth Sciences

 

Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2021 2 0 0
May 2021 2 0 0
Jun 2021 9 0 0
Jul 2021 1 0 0
Aug 2021 2 0 0
Sep 2021 1 0 0
Oct 2021 0 0 0