JPC - Journal of Planar Chromatography - Modern TLC
Volume/Issue:
Volume 20: Issue 1
A proposal for new RF equal-spread criteria with stable distribution as a random variable
Authors:
Łukasz Komsta Skubiszewski Medical University Department of Medicinal Chemistry Jaczewskiego 4 20-090 Lublin Poland

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Wojciech Markowski Skubiszewski Medical University Department of Physical Chemistry Staszica 6 20-081 Lublin Poland

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Genowefa Misztal Skubiszewski Medical University Department of Medicinal Chemistry Jaczewskiego 4 20-090 Lublin Poland

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Pages:
27–37
Online Publication Date:
07 Mar 2007
Publication Date:
01 Feb 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jpc.20.2007.1.4
Keywords:
TLC optimization; Retention; Chromatographic response function
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The retention factor RF is used in several criteria generally known as chromatographic response functions (CRF). In TLC and HPTLC most of these are based on differences between the retention factors of two substances, which are summed or multiplied. There are also other functions, for example the multispot response function ( MRF ) which enables the quality of a separation to be estimated. Although good CRF criteria should have well-defined distribution and range, current criteria based on the differences do not satisfy this requirement. Only MRF has a clearly defined range (0 to 1), but its distribution is unstable. In this paper two new independent coefficients: RU (retention uniformity) and RD (retention distance) are proposed; these always have values within the range 0 to 1 and stable density, irrespective of the number of compounds separated. Their reliable mathematical properties have been tested in wide range by Monte-Carlo simulations. An example is given of their use in the separation of fibrate-type antihyperlipidemic drugs by normal and reversed-phase TLC (114 systems).

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Cover JPC - Journal of Planar Chromatography - Modern TLC
JPC - Journal of Planar Chromatography - Modern TLC
Print ISSN:
0933-4173
Online ISSN:
1789-0993

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 6
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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