JPC - Journal of Planar Chromatography - Modern TLC
Volume/Issue:
Volume 20: Issue 1
TLC of quaternary pyridinium aldoximes, antidotes of organophosphorus esterase inhibitors
Authors:
Tamás Csermely Hospital of the Hungarian Defense Forces Department of Anesthesiology 1134 Budapest Robert K, körút 44 Hungary

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Georg Petroianu United Arab Emirates University Department of Pharmacology and Therapeutics Al Ain P.O. Box 17666 United Arab Emirates

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Kamil Kuca University of Defense Department of Toxicology, Faculty of Military Health Sciences Trebesska 1575 500 01 Hradec Kralove Czech Republic

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Józsel Fűrész Hungarian Defense Forces Institute of Health Protection 1555 Budapest P.O. Box 68 Hungary

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Ferenc Darvas ComInnex Zrt. 1031 Budapest Záhony u. 7 Hungary

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Zsolt Gulyás ComGrid Ltd 1031 Budapest Záhony u. 7 Hungary

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Rudolf Laufer Semmelweis University Department of Pharmacology and Pharmacotherapy 1089 Budapest Nagyvárad tér 4 Hungary

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Huba Kalász Semmelweis University Department of Pharmacology and Pharmacotherapy 1089 Budapest Nagyvárad tér 4 Hungary

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Pages:
39–42
Online Publication Date:
07 Mar 2007
Publication Date:
01 Feb 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jpc.20.2007.1.5
Keywords:
Hydrophilicity; Pyridinium aldoximes; K-27; K-48
Restricted access

Quaternary pyridinium aldoximes have been analyzed by thin-layer chromatography. Their separation was adequate when silica plates were used with a mobile phase with a high water content. As a consequence of their limited migration, reversed-phase TLC was not appropriate for determination of the lipophilicity of quaternary pyridinium aldoximes. Displacement TLC of some quaternary pyridinium aldoximes is, nevertheless, possible using silica as stationary phase with water-acetone-hydrochloric acid mobile phases. Normal-phase TLC with different concentrations of organic modifier gave a series of RM values for the pyridinium aldoximes. Approximation of the different plots of RM against organic modifier concentration to straight lines afforded RM,0 values and the slopes of the lines. The RM,0 values and the slopes both serve as indicators of the hydrophilic character of the compounds.

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Cover JPC - Journal of Planar Chromatography - Modern TLC
JPC - Journal of Planar Chromatography - Modern TLC
Print ISSN:
0933-4173
Online ISSN:
1789-0993

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 6
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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