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  • 1 Hospital of the Hungarian Defense Forces Department of Anesthesiology 1134 Budapest Robert K, körút 44 Hungary
  • 2 United Arab Emirates University Department of Pharmacology and Therapeutics Al Ain P.O. Box 17666 United Arab Emirates
  • 3 University of Defense Department of Toxicology, Faculty of Military Health Sciences Trebesska 1575 500 01 Hradec Kralove Czech Republic
  • 4 Hungarian Defense Forces Institute of Health Protection 1555 Budapest P.O. Box 68 Hungary
  • 5 ComGrid Ltd 1031 Budapest Záhony u. 7 Hungary
  • 6 ComInnex Zrt. 1031 Budapest Záhony u. 7 Hungary
  • 7 Semmelweis University Department of Pharmacology and Pharmacotherapy 1089 Budapest Nagyvárad tér 4 Hungary
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Quaternary pyridinium aldoximes have been analyzed by thin-layer chromatography. Their separation was adequate when silica plates were used with a mobile phase with a high water content. As a consequence of their limited migration, reversed-phase TLC was not appropriate for determination of the lipophilicity of quaternary pyridinium aldoximes. Displacement TLC of some quaternary pyridinium aldoximes is, nevertheless, possible using silica as stationary phase with water-acetone-hydrochloric acid mobile phases. Normal-phase TLC with different concentrations of organic modifier gave a series of RM values for the pyridinium aldoximes. Approximation of the different plots of RM against organic modifier concentration to straight lines afforded RM,0 values and the slopes of the lines. The RM,0 values and the slopes both serve as indicators of the hydrophilic character of the compounds.

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