JPC - Journal of Planar Chromatography - Modern TLC
Volume/Issue:
Volume 20: Issue 2
Pharmacokinetic analysis of ursolic acid in Alstonia scholaris R. Br. by high-performance thin-layer chromatography
Authors:
Prabha Shetty S.P. Mandali’s Ramnarain Ruia College Matunga, Mumbai-19 India

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Kiran Mangaonkar Shri Vile Parle Kelvani Mandal’s Mithibai College Mumbai-56 India

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Ramesh Sane Guru Nanak Institute for R&D Mumbai-19 India

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Kamlakar Jaripatke S.P. Mandali’s Ramnarain Ruia College Matunga, Mumbai-19 India

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Shweta Singh S.P. Mandali’s Ramnarain Ruia College Matunga, Mumbai-19 India

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Pages:
117–120
Online Publication Date:
23 Apr 2007
Publication Date:
01 Apr 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jpc.20.2007.2.8
Keywords:
HPTLC; Pharmacokinetics; Alstonia scholaris R. Br; Ursolic acid
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A simple and rapid high-performance thin-layer chromatographic method has been established and validated for determination of ursolic acid in rabbit plasma after ingestion of an aqueous slurry of Alstonia scholaris R. Br. leaves. Chromatography was performed on silica gel HPTLC plates with toluene-ethyl acetate-triethyl-amine-methanol, 7 + 2 + 1 + 1 ( v / v ), as mobile phase. The plates were scanned densitometrically at λ = 366 nm. The response to ursolic acid in spiked plasma was a linear function of concentration in the range 10 to 80 μg mL −1 . The detection and quantification limits were 3.0 and 10 μg mL −1 , respectively. The method has been successfully used to study the pharmacokinetics of Alstonia scholaris R. Br. using ursolic acid as a marker.

  • B.L. Manjunath , The Wealth of India, Vol. 1, Council of Scientific and Industrial Research, New Delhi, 1948.

    Manjunath B.L. , '', in The Wealth of India, Vol. 1 , (1948 ) -.

  • L.M. Perry , Medicinal Plants of East and Southeast Asia: Attributed properties and uses, MIT Press, Massachusetts, 1980.

    Perry L.M. , '', in Medicinal Plants of East and Southeast Asia: Attributed properties and uses , (1980 ) -.

  • E. Woodley , Medicinal plants of Papua New Guinea, part I, Josef Margrave Scientific Books, Weikersheim, Germany, 1991.

    Woodley E. , '', in Medicinal plants of Papua New Guinea, part I, Josef Margrave Scientific Books , (1991 ) -.

  • I.C. Chopra, R.N. Chopra , and S.L. Nayar , Glossary of Indian Medicinal Plants, CSIR, New Delhi, 1956.

    Nayar S.L. , '', in Glossary of Indian Medicinal Plants , (1956 ) -.

  • M. Krishnaswamy and K.K. Purushothaman , J. Res. Ay. Sid 4 (1–4) (1980) 111–114.

    Purushothaman K.K. , '' (1980 ) 4 J. Res. Ay. Sid : 111 -114 .

  • C.U. Devi, H. Joshi , and N. Valecha , Curr. Sci. 78 (2000) 1120–1122.

    Valecha N. , '' (2000 ) 78 Curr. Sci. : 1120 -1122 .

  • A. Banerji and J. Banerji , Indian J. Chem. 15B (1977) 390–391.

    Banerji J. , '' (1977 ) 15B Indian J. Chem. : 390 -391 .

  • D.N. Dhar, P. Dwiwedi , and S.C. Suri , Planta Med 31 (1977) 33–34.

    Suri S.C. , '' (1977 ) 31 Planta Med : 33 -34 .

  • L. Jie , J. Ethnopharmacol. 49 (1995) 57–68.

    Jie L. , '' (1995 ) 49 J. Ethnopharmacol. : 57 -68 .

  • V. Gopalkrishnan, K. Rajandra Prasad , and V. Rao , Indian Drugs 38 (2001) 216–224.

    Rao V. , '' (2001 ) 38 Indian Drugs : 216 -224 .

  • D. Baricevic, S. Sosa, R. DellaLoggia, A. Tubaro, B. Simonovska, A. Krasna , and A. Zupancic , J. Ethnopharmacol. 75 (2001) 125–132.

    Zupancic A. , '' (2001 ) 75 J. Ethnopharmacol. : 125 -132 .

  • P. Shetty, K.V. Mangaonkar , and R.T. Sane , J. Planar Chromatogr. 20 (2007) 65–68.

    Sane R.T. , '' (2007 ) 20 J. Planar Chromatogr. : 65 -68 .

  • I.A. Murav’ev, V.V. Shatilo , and V.F. Semenchenko , Chem. Nat. Prod. 8 (1974) 720–721.

    Semenchenko V.F. , '' (1974 ) 8 Chem. Nat. Prod. : 720 -721 .

  • L. Lacikova, M.E. Abdel-Hamid , and L. Novotny , Chromatographia 63 (2006) 117–122.

    Novotny L. , '' (2006 ) 63 Chromatographia : 117 -122 .

  • L. Novotny, M.E. Abdel-Hamid , and H. Hamza , J. Pharm. Biomed. Anal. 31 (2003) 961–968.

    Hamza H. , '' (2003 ) 31 J. Pharm. Biomed. Anal. : 961 -968 .

  • L.H. Yang, L.H. Zhao , and D.N. Zhu , Zonh Guo Zong Yao Za Zhi 14 (1994) 30–32.

    Zhu D.N. , '' (1994 ) 14 Zonh Guo Zong Yao Za Zhi : 30 -32 .

  • S.M. Zhang, G. Hong , and J.M. Chen , Chin. J. Anal. Chem. 28 (2000) 129–131.

    Chen J.M. , '' (2000 ) 28 Chin. J. Anal. Chem. : 129 -131 .

  • Q. Liao, W. Yang, Y. Jia, X. Chen, Q. Gao , and K. Bi , Yakugaku Zasshi, 125 (2005) 509–515.

    Bi K. , '' (2005 ) 125 Yakugaku Zasshi : 509 -515 .

  • X.T. Yang, L.L. Cheng , and K. Mi , Shanghai Zhong Yi Yao Da Xue Xue Bao 15 (2001) 53–55.

    Mi K. , '' (2001 ) 15 Shanghai Zhong Yi Yao Da Xue Xue Bao : 53 -55 .

  • P.D. Sethi , High-Performance Thin-Layer Chromatographic Quantitative Analysis of Pharmaceutical Formulations, CBS, India, 1996.

    Sethi P.D. , '', in High-Performance Thin-Layer Chromatographic Quantitative Analysis of Pharmaceutical Formulations , (1996 ) -.

  • J.B. Harborne , Phytochemical Methods, Springer, Berlin, 2005.

    Harborne J.B. , '', in Phytochemical Methods , (2005 ) -.

  • V.K. Bhargava, S.K. Garg , and R.S. Karan , J. Ethnopharmacol. 64 (1999) 259–264.

    Karan R.S. , '' (1999 ) 64 J. Ethnopharmacol. : 259 -264 .

  • K.K. Jaripatke, R.T. Sane, S. Shailajan , and S.N. Menon , J. Planar Chromatogr. 17 (2004) 483–485.

    Menon S.N. , '' (2004 ) 17 J. Planar Chromatogr. : 483 -485 .

  • S. Badami, G. Mahesh Kumar, N. Mathew, N.S. Meyyanathan, B. Suresh , and D.J. Bendell , J. Planar Chromatogr. 15 (2002) 183–186.

    Bendell D.J. , '' (2002 ) 15 J. Planar Chromatogr. : 183 -186 .
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Cover JPC - Journal of Planar Chromatography - Modern TLC
JPC - Journal of Planar Chromatography - Modern TLC
Print ISSN:
0933-4173
Online ISSN:
1789-0993

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 6
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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