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  • 1 Prin. K.M. Kundnani College of Pharmacy Plot No. 23, Jote Joy Building, Rambhau Salgaonkar Marg Cuffe Parade, Colaba, Mumbai 400 005 India
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The oleo-gum-resin known as ‘guggul’, obtained from the plant Commiphora mukul , Hook (family Burseraceae), is widely used, as a component of formulations containing other Ayurvedic drugs, for treatment of hypercholesterolemia, rheumatism, and arthritis. Chemically, guggul contains two active keto steroids, guggulsterones E and Z , which are reported to be responsible for its antihyperlipidemic activity. These cis and trans isomers have been isolated, purified by TLC and column chromatography, and characterized by determination of melting point and by acquisition of UV, IR, and NMR spectra. After confirmation of their identity, they were used as biomarkers in HPTLC fingerprinting analysis of five commercial Ayurvedic formulations, four tablets and a capsule, all of which contain guggul as a constituent. The analytical method was fully validated. Extrapolation was used to calculate probable amounts of guggul added to the formulations on the basis of E and Z isomer content.

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