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  • 1 Indian Institute of Technology Department of Chemistry Roorkee 247667 India
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Resolution of racemic metoprolol, propranolol, carvedilol, bisoprolol, salbutamol, and labetalol, commonly used β-blockers, into their enantiomers has been achieved by TLC on silica gel plates impregnated with optically pure L -Glu and L -Asp. Acetonitrile-methanol-water-dichloromethane and acetonitrile-methanol-water-glacial acetic acid mobile phases in different proportions enabled successful separation. The spots were detected with iodine vapor. The detection limits were 0.23, 0.1, 0.27, 0.25, 0.2, and 0.2 μg for each enantiomer of metoprolol, propranolol, carvedilol, bisoprolol, salbutamol, and labetalol, respectively.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
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1988
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1
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Springer Nature Switzerland AG
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ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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