Authors:
Bipin Mehta University of Mumbai Department of Chemistry Vidaynagari, Santacruz [E] Mumbai 400098 India

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Sachin Morge University of Mumbai Department of Chemistry Vidaynagari, Santacruz [E] Mumbai 400098 India

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A simple, rapid and precise high-performance thin-layer chromatographic (HPTLC) method for analysis of candesartan cilexetil and hydrochlorothiazide in their tablet dosage forms has been developed and validated. Chromatography was performed on silica gel 60 GF 254 plates with acetone-chloroform-ethyl acetate-methanol 3:3:3:0.5 ( v/v ) as mobile phase. Detection was performed at 280 nm. The RF values were 0.27 for candesartan cilexetil and 0.45 for hydrochlorothiazide. Regression plots revealed good linear relationships in the concentration ranges 50.6–253.0 μg for hydrochlorothiazide and 65.0–325.0 μg for candesartan cilexetil. When accuracy was checked by conducting recovery studies, average recovery was 99.78% and 98.09% for candesartan cilexetil and hydrochlorothiazide, respectively. The amounts of the drugs in the marketed formulation were 100.26%. and 99.28% for candesartan cilexetil and hydrochlorothiazide, respectively.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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