JPC - Journal of Planar Chromatography - Modern TLC
Volume/Issue:
Volume 21: Issue 5
Determination of the lipophilicity of some psychotropic drugs by RP-TLC
Authors:
Anna Hawrył Medical University Department of Inorganic Chemistry, Faculty of Pharmacy 6 Staszica 20-081 Lublin Poland

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Daniel Cichocki Medical University Department of Inorganic Chemistry, Faculty of Pharmacy 6 Staszica 20-081 Lublin Poland

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Monika Waksmundzka-Hajnos Medical University Department of Inorganic Chemistry, Faculty of Pharmacy 6 Staszica 20-081 Lublin Poland

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Pages:
343–348
Online Publication Date:
22 Oct 2008
Publication Date:
01 Oct 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jpc.21.2008.5.5
Keywords:
Psychotropic drugs; R MW ; log P; Lipophilicity; RP-18F 254
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Psychotropic drugs have been chromatographed on RP-18-HPTLC plates with mobile phases containing water, an organic modifier (methanol, dioxane, acetone, acetonitrile or tetrahydrofuran), and ion-pair reagents or ammonia. RF was measured for different concentrations of organic modifier. Relationships between solute retention and modifier concentration were described by the Soczewiński-Wachtmeister and Schoenmaker equations. The equations were used to determine RMW by the extrapolation method. Calculated values of RMW or C were correlated with log P values for the drugs, estimated by use of software. Significant correlations between the intercept ( RMW ) and slope ( S ) of the linear equations were also calculated. Chromatographic systems for which the RMW values obtained were close to calculated log P values can be used for determination of the lipophilicity of basic drugs.

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Cover JPC - Journal of Planar Chromatography - Modern TLC
JPC - Journal of Planar Chromatography - Modern TLC
Print ISSN:
0933-4173
Online ISSN:
1789-0993

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 6
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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