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  • 1 Medical University Department of Inorganic Chemistry, Faculty of Pharmacy 6 Staszica 20-081 Lublin Poland
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Psychotropic drugs have been chromatographed on RP-18-HPTLC plates with mobile phases containing water, an organic modifier (methanol, dioxane, acetone, acetonitrile or tetrahydrofuran), and ion-pair reagents or ammonia. RF was measured for different concentrations of organic modifier. Relationships between solute retention and modifier concentration were described by the Soczewiński-Wachtmeister and Schoenmaker equations. The equations were used to determine RMW by the extrapolation method. Calculated values of RMW or C were correlated with log P values for the drugs, estimated by use of software. Significant correlations between the intercept ( RMW ) and slope ( S ) of the linear equations were also calculated. Chromatographic systems for which the RMW values obtained were close to calculated log P values can be used for determination of the lipophilicity of basic drugs.

  • C. Hansch, T. Fujita , J. Am. Soc. 86 (1964) 1616–1626.

    Fujita T. , '' (1964 ) 86 J. Am. Soc. : 1616 -1626.

  • T. Fujita, J. Iwasa and C. Hansch , J. Am. Soc. 86 (1964) 5175–5180.

    Hansch C. , '' (1964 ) 86 J. Am. Soc. : 5175 -5180.

  • C. Hansch, P.P. Maloney and R.M. Muir , Nature 194 (1962) 178–180.

    Muir R.M. , '' (1962 ) 194 Nature : 178 -180.

  • C. Hansch, R.M. Muir, T. Fujita, P.P. Maloney, C.F. Geiger and M.J. Streich , J. Am. Soc. 85 (1963) 2817–2821.

    Streich M.J. , '' (1963 ) 85 J. Am. Soc. : 2817 -2821.

  • G.L. Biagi, A.M. Barbaro, A. Sapone, P.A. Borea, K. Varani, M. Recanatini , J. Chromatogr. A 723 (1996) 135–143.

    Recanatini M. , '' (1996 ) 723 J. Chromatogr. A : 135 -143.

  • T. Sławik, C. Kowalski , J. Chromatogr. A 952 (2002) 295–299.

    Kowalski C. , '' (2002 ) 952 J. Chromatogr. A : 295 -299.

  • C. Erbu, B. Malawska , J. Liq. Chrom. Rel. Technol. 23 (2000) 2143–2154.

    Malawska B. , '' (2000 ) 23 J. Liq. Chrom. Rel. Technol. : 2143 -2154.

  • N.U. Perišić-Janjić T.Lj. Djaković-Sekulić, L.R. Jevrić and B.Ž. Jovanović , J. Planar Chromatogr. 18 (2005) 212–216.

    Jovanović B. , '' (2005 ) 18 J. Planar Chromatogr. : 212 -216.

  • J.D. Veličzković, Ž.Lj. Tešić and D.M. Milojković-Opsenica , J. Planar Chromatogr. 18 (2005) 358–363.

    Milojković-Opsenica D.M. , '' (2005 ) 18 J. Planar Chromatogr. : 358 -363.

  • N.U. Perišić-Janjić, G.S. Usčumlić and N.V. Valentić , J. Planar Chromatogr. 18 (2005) 92–97.

    Valentić N.V. , '' (2005 ) 18 J. Planar Chromatogr. : 92 -97.

  • N.U. Perišić-Janjić, B. Lučić, N.J. Janjić and D. Agbaba , J. Planar Chromatogr. 16 (2003) 347–350.

    Agbaba D. , '' (2003 ) 16 J. Planar Chromatogr. : 347 -350.

  • T.Lj. Djaković-Sekulić, N.U. Perišić-Janjić and S.D. Petrović , J. Planar Chromatogr. 16 (2003) 147–153.

    Petrović S.D. , '' (2003 ) 16 J. Planar Chromatogr. : 147 -153.

  • A. Pyka , J. Planar Chromatogr. 17 (2004) 275–279.

    Pyka A. , '' (2004 ) 17 J. Planar Chromatogr. : 275 -279.

  • P. Kastner, J. Klimes, P. Velenovska and V. Klimesova , J. Liq. Chrom. Rel. Technol. 25 (2002) 2849–2856.

    Klimesova V. , '' (2002 ) 25 J. Liq. Chrom. Rel. Technol. : 2849 -2856.

  • H. Karajiannis, H. van de Waterbeemd , Pharm. Acta Helv. 70 (1995) 67–77.

    Waterbeemd H. , '' (1995 ) 70 Pharm. Acta Helv. : 67 -77.

  • U. Kijkowska-Murak, D. Matosiuk, A. Hawrył, M. Waksmundzka-Hajnos, B. Kuran and J. Kossakowski , J. Liq. Chrom. Rel. Technol. 29 (2006) 2019–2033.

    Kossakowski J. , '' (2006 ) 29 J. Liq. Chrom. Rel. Technol. : 2019 -2033.

  • A. Detroyer, V. Schoonjans, F. Questier, Y. Vander Heyden, A.P. Borosy, Q. Guo, D.L. Massart , J. Chromatogr. A 897 (2000) 23–36.

    Massart D.L. , '' (2000 ) 897 J. Chromatogr. A : 23 -36.

  • http://chem.sis.nlm.nih.gov/chemidplus/

  • N. Sadlej-Sosnowska and I. Śledzińska , J. Chromatogr. 595 (1992) 53–61.

    Śledzińska I. , '' (1992 ) 595 J. Chromatogr. : 53 -61.

  • A. Petruczynik, M. Waksmundzka-Hajnos, A. Hawrył and A. Ziółkowska , Chem. Anal. (Warsaw) 48 (2003) 881–890.

    Ziółkowska A. , '' (2003 ) 48 Chem. Anal. (Warsaw) : 881 -890.

  • H.H. Jaffe , Chem. Rev. 53 (1953) 191–196.

    Jaffe H.H. , '' (1953 ) 53 Chem. Rev. : 191 -196.

  • C. Sarbu, S. Todor , J. Chromatogr. A 822 (1998) 263–269.

    Todor S. , '' (1998 ) 822 J. Chromatogr. A : 263 -269.

  • http://www.vclab.org

  • S.M. Wu, H.L. Wu, W.K. Ko, S.H. Chen , Anal. Chim. Acta 413 (2000) 125–129.

    Chen S.H. , '' (2000 ) 413 Anal. Chim. Acta : 125 -129.

  • K. Croes, P.T. McCarthy, R.J. Flanagan , J. Chromatogr. A 693 (1995) 289–306.

    Flanagan R.J. , '' (1995 ) 693 J. Chromatogr. A : 289 -306.

  • N.M. Vieno, T. Tuhkanen, L. Kronberg , J. Chromatogr. A 1134 (2006) 101–111.

    Kronberg L. , '' (2006 ) 1134 J. Chromatogr. A : 101 -111.

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