JPC - Journal of Planar Chromatography - Modern TLC
Volume/Issue:
Volume 22: Issue 3
Planar chromatography of cholic acid-derived cis-trans isomeric bis-steroidal tetraoxanes
Authors:
Sandra Šegan Technology and Metallurgy Institute of Chemistry Njegoševa 12 11000 Belgrade Serbia

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Dejan Opsenica Technology and Metallurgy Institute of Chemistry Njegoševa 12 11000 Belgrade Serbia

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Bogdan Šolaja University of Belgrade Faculty of Chemistry P.O. Box 51 11158 Belgrade Serbia

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Dušanka Milojković-Opsenica University of Belgrade Faculty of Chemistry P.O. Box 51 11158 Belgrade Serbia

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Pages:
175–181
Online Publication Date:
18 Jun 2009
Publication Date:
01 Jun 2009
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jpc.22.2009.3.3
Keywords:
Planar chromatography; cis-trans Isomers; bis-Steroidal tetraoxanes; Separation mechanisms
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Seven pairs of cis-trans isomers of bis-steroidal tetraoxanes have been examined by both normal-phase (NP) and reversed-phase (RP) planar chromatography. Unmodified silica gel was used with ethyl acetate-toluene and ethyl acetate-petroleum ether as mobile phases in typical normal-phase systems. CN-silica with the mobile phases methanol-water and acetone-water and RP-18 silica with water-organic modifier (methanol, acetone, or dioxane) mobile phases were used as reversed-phase systems. For the RP systems a good linear correlation was established between RM values and amount ([%] ν/ν ) of organic modifier in the mobile phase (usually r > 0.99). It was found that under both NP and RP conditions cis isomers were more weakly retained than the corresponding trans isomers. The only exception to this was the chromatographic behavior of C(24) methyl esters. It was established that increasing the polarity of substituents at C(24) and C(24a) led to stronger retention in NP systems, i.e. weaker retention in RP systems. Highly selective separation was achieved in all the chromatographic systems investigated. Possible separation mechanisms are discussed on the basis of the results obtained.

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Cover JPC - Journal of Planar Chromatography - Modern TLC
JPC - Journal of Planar Chromatography - Modern TLC
Print ISSN:
0933-4173
Online ISSN:
1789-0993

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 6
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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