JPC - Journal of Planar Chromatography - Modern TLC
Volume/Issue:
Volume 22: Issue 6
HPTLC analysis of olmesartan medoxomil and hydrochlorothiazide in combination tablet dosage forms
Authors:
Sayali Kadukar AISSMS College of Pharmacy Department of Pharmaceutical Analysis Kennedy Road, Near R.T.O. Pune 411 001 Maharashtra India

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Santosh Gandhi AISSMS College of Pharmacy Department of Pharmaceutical Analysis Kennedy Road, Near R.T.O. Pune 411 001 Maharashtra India

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Poonam Ranjane AISSMS College of Pharmacy Department of Pharmaceutical Analysis Kennedy Road, Near R.T.O. Pune 411 001 Maharashtra India

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Sandeep Ranher AISSMS College of Pharmacy Department of Pharmaceutical Analysis Kennedy Road, Near R.T.O. Pune 411 001 Maharashtra India

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Pages:
425–428
Online Publication Date:
28 Dec 2009
Publication Date:
01 Dec 2009
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jpc.22.2009.6.7
Keywords:
Olmesartan medoxomil; Hydrochlorothiazide; Densitometric method; Quantitative analysis
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A new simple, accurate, and precise densitometric method for determination of olmesartan medoxomil (OM) and hydrochlorothiazide (HTZ) in combined tablet dosage forms has been developed and validated. Separation of the drugs was carried out using chloroform-methanol-toluene 6:4:5 ( v/v ) as mobile phase on precoated silica gel 60 F 254 plates. The retention factors for HTZ and OM were 0.40 ± 0.019 and 0.58 ± 0.013, respectively. The detection of bands was carried out at 258 nm. The calibration curve was linear in the concentration range 100 to 600 ng per band for OM and 50 to 300 ng per band for HTZ. For OM, the recovery study results ranged from 99.92 to 100.82% with RSD values ranging from 0.300 to 0.851%. For HTZ, the recovery results ranged from 99.21 to 100.34% with RSD values ranging from 0.203 to 0.489%. The assay [%] was 99.989 ± 0.389 and 99.516 ± 0.303 for OM and 100.35 ± 0.609 and 100.17 ± 0.595 for HTZ (mean ± S.D., n = 6), respectively, in two different tablet formulations tested. The method can be used for routine analysis of these drugs in combined tablet dosage forms in quality-control laboratories.

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Cover JPC - Journal of Planar Chromatography - Modern TLC
JPC - Journal of Planar Chromatography - Modern TLC
Print ISSN:
0933-4173
Online ISSN:
1789-0993

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 6
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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