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  • 1 Islamic Azad University Department of Chemistry, Central Tehran Branch Tehran Iran
  • | 2 Islamic Azad University Department of Science, Varamin (Pishva) Branch Tehran Iran
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A new, simple, accurate, and precise HPTLC method has been established for separation and simultaneous analysis of aspirin, salicylic acid, and sulfosalicylic acid. Standard and sample solutions of aspirin, salicylic acid and sulfosalicylic acid were applied to aluminum foil silica gel G 60 F 254 HPTLC plates impregnated with 2% ( w/v ) boric acid in ethanol. The plates were developed with chloroform-methanol-ammonia-water 120:75:2:6 ( v/v ) as mobile phase. UV detection was performed densitometrically at 254 nm. The retention factors of aspirin, salicylic acid, and sulfosalicylic acid were 0.81, 0.61, and 0.24, respectively. The linear range was 100–1000 ng per band for all three compounds, and the correlation coefficients, R2 , were 0.97, 0.94, and 0.95, respectively. The limits of quantification (LOQ) were 122.81, 94.86, and 60.50 ng, respectively, and the respective limits of detection (LOD) were 36.84, 36.84, and 18.14 ng. Analysis of standard solutions revealed precision and repeatability were good for all the compounds studied.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
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6
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Springer Nature Switzerland AG
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ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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