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Monika DąbrowskaJagiellonian University, Collegium Medicum Department of Inorganic and Analytical Chemistry Medyczna 9 Kraków Poland

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Małgorzata StarekJagiellonian University, Collegium Medicum Department of Inorganic and Analytical Chemistry Medyczna 9 Kraków Poland

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Sabina PikulskaJagiellonian University, Collegium Medicum Department of Inorganic and Analytical Chemistry Medyczna 9 Kraków Poland

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A rapid, accurate, and sensitive densitometric TLC method has been established and validated for simultaneous analysis of eight β-lactam antibiotics (cephalexin, cefadroxil, and cefazolin (first-generation), cefaclor, cefuroxime, and cefuroxime axetil (second-generation), and ceftriaxone and cefotaxime (third-generation)). Chromatographic separation was achieved on silica gel F254 plates with chloroform-ethyl acetate-glacial acetic acid-water 4:4:4:1 (v/v) as mobile phase. Densitometric detection was performed at 275 nm. Statistical evaluation showed the performance of the method was satisfactory. Accuracy was in the range 98.30–100.85% and precision, as RSD, was from 0.4 to 2.45%.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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