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Bahia Moussa Cairo University Pharmaceutical Chemistry Department, Faculty of Pharmacy Kasr El-Aini Street Cairo 115562 Egypt

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Marwa Mohamed National Organization for Drug Control and Research (NODCAR) 6 Abo Hazem Street, Pyramids Avenue Post Office Box 29 Cairo Egypt postal code: 12553

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Nadia Youssef National Organization for Drug Control and Research (NODCAR) 6 Abo Hazem Street, Pyramids Avenue Post Office Box 29 Cairo Egypt postal code: 12553

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A simple, rapid, and selective densitometric thin-layer chromatographic (TLC) method has been established and validated for simultaneous quantitative analysis of olmesartan medoxomil and hydrochlorothiazide in the presence of olmesartan medoxomil degradation products. Chromatography was performed on aluminum foil-backed HPTLC plates coated with 0.2 mm layers of nano-silica gel 60 F254 as stationary phase. RF values of olmesartan medoxomil, its degradation products, and hydrochlorothiazide were significantly different when chloroform-methanol-formic acid 8:1.5:0.5 (v/v) was used as mobile phase. Detection was performed at 260 nm and 272 nm for olmesartan medoxomil and hydrochlorothiazide, respectively. Regression plots revealed good linear relationships in the concentration range 0.05–1 mg mL−1. Accuracy was checked by conducting recovery studies; average recovery was 100.35 ± 1.060 and 99.91 ± 1.154 for olmesartan medoxomil and hydrochlorothiazide, respectively. The amounts of the drugs in the dosage formulation were 102.78 ± 1.525% of the label claim for olmesartan medoxomil and 103.09 ± 1.259 for hydrochlorothiazide. Method validation was performed in accordance with USP guidelines.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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