Authors:
Małgorzata Starek Jagiellonian University Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Collegium Medicum Medyczna 9 Kraków Poland

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Szymon Łaskawski Jagiellonian University Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Collegium Medicum Medyczna 9 Kraków Poland

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Monika Dąbrowska Jagiellonian University Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Collegium Medicum Medyczna 9 Kraków Poland

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A simple, selective, and sensitive thin-layer chromatography (TLC) method is described for the identification and determination of nabumetone in pharmaceutical products. The mobile phase was constituted by the following mixture: n-hexane-chloroform-glacial acetic acid 4:1:1 (ν/ν/ν); and the stationary phase was TLC plate of silica gel 60 F254. The chromatograms were developed and analyzed densitometrically at λ1 = 270 nm and λ2 = 330 nm. RF values and UV spectra were used to identify the compounds. The developed method was characterized by high sensitivity (LOD and LOQ (limits of detection and quantitation) from 0.23 μg per band to 1.00 mg per band), high accuracy (recovery about 100%), and good precision ((relative standard deviation, RSD < 2%).

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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