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  • 1 Medical University Department of Pharmaceutical Chemistry, Faculty of Pharmacy 2 Dunav Str. Sofia 1000 Bulgaria
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The antihypertensive effect of sartans is a result of inhibition of the binding of angiotensin (AT) II to the AT1 receptor in vascular smooth muscle. The aim of current study is to apply the validated thin-layer chromatography (TLC)-densitometric method for simultaneous identification and determination of losartan potassium, telmisartan, and valsartan in tablets, by using the following chromatographic system:stationary phase:TLC plates with silica gel G60 F254, mobile phase: 7.5:1.5:5:5:0.01:0.03 = CHCl3-CH3OH-acetone-toluene-CH3COOH, ultraviolet detection at λ= 254 nm, and densitometer CAMAG. Accuracy is represented by the values of the degree of recovery R (%) and relative standard deviation (RSD). All data for R correspond to the relevant confidence interval $ - \bar X - t.S\bar X \div \bar X + t.S\bar X$: tablet Lorista® 99.43 ÷ 102.59, RSD = 1.15; tablet Losap®: 99.37 ÷ 101.87, RSD = 0.89; tablet Micardis®: 99.19 ÷ 99.97, RSD = 0.36; tablet Valtensin®: 98.74 ÷ 101.1, RSD = 0.85. Precision is estimated by the uncertainty of the result, determined by standard deviation (SD), RSD, and confidence interval. All data for the obtained quantity of sartans (C) suit their respective confidence interval: tablet Lorista®: 49.69 ÷ 51.31 (SD = 0.58; RSD = 1.15); tablet Lozap®: 49.7 ÷ 50.92 (SD = 0.45; RSD = 0.89); tablet Micardis®: 79.35 ÷ 79.97 (SD = 0.29; RSD = 0.36); tablet Valtensin®: 157.99 ÷ 161.77 (SD = 1.36; RSD = 0.85).Conclusion: the applied TLC-densitometric method is appropriate for quality control of sartans in dosage drug products — tablets.

  • G.K. Aulakh, R.K. Sodhia, M. Singha, Life Sci. 81 (2007) 615–639.

    Singha M. , '' (2007 ) 81 Life Sci. : 615 -639.

  • E.D. Deeks, Am. J. Cardiovasc. Drugs 9 (2009) 411–418.

    Deeks E.D. , '' (2009 ) 9 Am. J. Cardiovasc. Drugs : 411 -418.

  • T. Ogihara, T. Saruta, K. Shimamoto, H. Matsuoka, H. Rakugi, Hypertens. Res. 31 (2008) 281–287.

    Rakugi H. , '' (2008 ) 31 Hypertens. Res. : 281 -287.

  • M. Shargorodsky, E. Hass, M. Boaz, D. Gavish, R. Zimlichman, Atherosclerosis 197 (2008) 303–310.

    Zimlichman R. , '' (2008 ) 197 Atherosclerosis : 303 -310.

  • R.D. Smith, H. Yokoyama, D.B. Averill, E.L. Schiffrin, C.M. Ferrario, J. Am. Soc. Hypert. 2 (2008) 165–172.

    Ferrario C.M. , '' (2008 ) 2 J. Am. Soc. Hypert. : 165 -172.

  • R. Lakhdar, M.H. Al-Mallah, D.E. Lanfear, J. Card. Fail. 14 (2008) 181–188.

    Lanfear D.E. , '' (2008 ) 14 J. Card. Fail. : 181 -188.

  • J. Ahmad, Clin. Res. Rev. 2 (2008) 135–158.

    Ahmad J. , '' (2008 ) 2 Clin. Res. Rev. : 135 -158.

  • A.K. Sjîlie, Diabetes Res. Clin. Pract. 76 (2007) S 31–S 39.

    Sjîlie A.K. , '' (2007 ) 76 Diabetes Res. Clin. Pract. : S 31 -S 39.

  • V. Papademetriou, Am. Heart J. 157 (2009) S 24–S 30.

    Papademetriou V. , '' (2009 ) 157 Am. Heart J. : S 24 -S 30.

  • J. Östergren, Diabetes Res. Clin. Pract. 76 (2007) S13–S21.

    Östergren J. , '' (2007 ) 76 Diabetes Res. Clin. Pract. : S13 -S21.

  • F.P.C. Catapano, P. Chiodini, M.L. De Nicola, R. Minutolo, P. Zamboli, C. Gallo, G. Conte, Am. J. Kidney Dis. 52 (2008) 475–485.

    Conte G. , '' (2008 ) 52 Am. J. Kidney Dis. : 475 -485.

  • M.M. Baing, V.V. Vaidya, R.T. Sane, S.N. Menon, K. Dalvi, Chromatographia 64 (2006) 293–296.

    Dalvi K. , '' (2006 ) 64 Chromatographia : 293 -296.

  • N.K. Ramadan, H.M. Mohamed, A.A. Moustafa, Anal. Lett. 43 (2010) 570–581.

    Moustafa A.A. , '' (2010 ) 43 Anal. Lett. : 570 -581.

  • M.C. Damle, K.G. Bothar, K.S. Topagi, J. Pharm. Res. 8 (2009) 198–201.

    Topagi K.S. , '' (2009 ) 8 J. Pharm. Res. : 198 -201.

  • A. Gumieniczek, T. Inglot, A. Kończak, J. Planar Chromatogr. 24 (2011) 99–104.

    Kończak A. , '' (2011 ) 24 J. Planar Chromatogr. : 99 -104.

  • B. Moussa, M. Mohamed, N. Youssef, J. Planar Chromatogr. 24 (2011) 35–39.

    Youssef N. , '' (2011 ) 24 J. Planar Chromatogr. : 35 -39.

  • B.H. Mehta, S.B. Morge, J. Planar Chromatogr. 21 (2008) 173–176.

    Morge S.B. , '' (2008 ) 21 J. Planar Chromatogr. : 173 -176.

  • S.S. Kadukar, S.V. Gandhi, P.N. Ranjane, S.S. Ranher, J. Planar Chromatogr. 22 (2009) 425–428.

    Ranher S.S. , '' (2009 ) 22 J. Planar Chromatogr. : 425 -428.

  • S.R. Sathe, S.B. Bari, Acta Chromatogr. 19 (2007) 270–278.

    Bari S.B. , '' (2007 ) 19 Acta Chromatogr. : 270 -278.

  • D. Tsvetkova, D. Obreshkova, S. Ognjanov, Comp. Rend. Acad. Bulg. Sci. 64 (2011) 39–44.

    Ognjanov S. , '' (2011 ) 64 Comp. Rend. Acad. Bulg. Sci. : 39 -44.

  • N.P. Dimov, Industrial Pharmacy — Science and Technology Series. Chromatography in Pharmaceutical Analysis, NIHFI, Sofia, 1999.

    Dimov N.P. , '', in Industrial Pharmacy — Science and Technology Series , (1999 ) -.

  • J.P. Taylor, An Introduction to Error Analysis. 2nd edn., University Science Books, Sausalito, California, 1997, pp. 166–168.

    Taylor J.P. , '', in An Introduction to Error Analysis , (1997 ) -.

  • G. Upton, I. Cook (eds.), Oxford Dictionary of Statistics, Oxford University Press, Oxford, 2008.

    '', in Oxford Dictionary of Statistics , (2008 ) -.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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