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Areej Al-TaweelKing Saud University Department of Pharmacognosy, College of Pharmacy P.O. Box 2457 Riyadh 11451 Saudi Arabia

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Saleh AlqasoumiKing Saud University Department of Pharmacognosy, College of Pharmacy P.O. Box 2457 Riyadh 11451 Saudi Arabia

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Prawez AlamSalman Bin Abdulaziz University Department of Pharmacognosy, College of Pharmacy P.O. Box 173 Al-Kharj 11942 Saudi Arabia

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Maged Abdel-Kader
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An attempt was made to develop and validate a simple, accurate high-performance thin-layer chromatographic (HPTLC) method for the simultaneous determination of diosmin, hesperidin, and ascorbic acid in pharmaceutical preparations. Analysis was performed on 10 cm × 20 cm aluminum-backed plates coated with 0.2 mm layers of silica gel 60 F254 (Merck, Germany). CAMAG TLC Scanner III was used for UV densitometric scanning. The used HPTLC system was found to give sharp, symmetrical, and well-resolved peaks at RF values of 0.34 ± 0.02, 0.40 ± 0.04, and 0.56 ± 0.03, and linearity was found in the ranges 100–800 ng/spot (r2 = 0.9985), 100–800 ng/spot (r2 = 0.9966), and 50–400 ng/spot (r2 = 0.9951) for diosmin, hesperidin, and ascorbic acid, respectively.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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