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  • 1 Indian Institute of Technology Roorkee Department of Chemistry Roorkee 247667 India
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Direct resolution of enantiomers of (±)-bupropion (BUP) was achieved by thin-layer chromatography on silica gel plates impregnated with optically pure l-Glu as chiral selector. The solvent system acetonitrile-methanol-dichloromethane-water (5.6:1:2.2:1, v/v) was successful in resolving the enantiomers. Spots were detected by use of iodine vapor. The detection limit was 0.2 μg for each enantiomer of BUP. The effects of concentration of chiral selector, temperature, and pH on enantiomeric resolution were examined. The separation of BUP enantiomers was also investigated by high-performance liquid chromatography (HPLC) on a chlorinated methylated cellulose-based stationary phase. Reversed phase HPLC was successful using binary mixture of aqueous ammonium formate and methanol for separation of enantiomeric pair with detection at 230 nm. The factors influencing HPLC separation were also investigated.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
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1988
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