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Rasha Youssef University of Alexandria, El-Messalah Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry Alexandria 21521 Egypt

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Essam Khamis University of Alexandria, El-Messalah Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry Alexandria 21521 Egypt

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Mahmoud El-Sayed University of Alexandria, El-Messalah Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry Alexandria 21521 Egypt

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Mona Abdel Moneim Pharos University of Alexandria Faculty of Pharmacy and Drug Manufacturing, Department of Pharmaceutical Chemistry Somouha, Canal El Mahmoudia Street Alexandria Egypt

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A highly validated and selective high-performance thin-layer chromatography (HPTLC) method was developed for the determination of cetirizine dihydrochloride (CET) with pseudoephedrine (PSE) and/or phenylpropanolamine (PPA) and paracetamol (PAR) in their pharmaceutical formulations. The proposed method was based on HPTLC separation of the drugs followed by densitometric measurements of their spots at 257 nm. Separation was carried out on Merck HPTLC aluminum sheets of silica gel 60 F254 using methanol-distilled water (9.95:0.05, v/v) as mobile phase. The linear regression analysis data were used for the regression line in the range of 1-4, 3–10, 4–8, and 5–100 μg band−1 for CET, PSE, PPA, and PAR, respectively. The proposed method was validated and successfully applied for the analysis of pharmaceutical formulations and laboratory-prepared mixtures containing the two multicomponent combinations. The method is validated and showed good performances in terms of linearity, sensitivity, precision, accuracy, and stability.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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