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  • 1 Medical University of Lublin Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland
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The retention (R M) values of nine one-point adsorption model compounds: diphenylamine, indol, 2-naphtol, 1-naphtol, 1-naphtylamine, 4-toluidine, carbazole, 4-chloraniline, and thymol were investigated on silica gel using six modifiers: acetone, dioxane, hexane, isopropanol, methylethylketone, ethyl acetate, and tetrahydrofurane (in hexane). These compounds showed small but visible curvilinearity of dependence of R M vs. modifier concentration. This curvilinearity is very similar among the investigated compounds, so relative differences of extrapolated R M are almost the same (strictly intercorrelated) regardless of the regression technique used. We have compared several robust and weighted regression methods and investigated their impact on extrapolated values. It can be concluded that one should primarily consider weighted regression with 1/x weights during retention extrapolation. It seems to be a better alternative than classical regression (better extrapolation) and also better than polynomial approaches (better stability).

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