JPC - Journal of Planar Chromatography - Modern TLC
Volume/Issue:
Volume 29: Issue 3
Genetic diversity in chemically diverse accessions of Bacopa monnieri
Authors:
Anshu Srivastava B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad — 380 054, Gujarat, India

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Gaurav Garg National Institute of Pharmaceutical Education and Research (NIPER) — Ahmedabad, c/o B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad — 380 054, Gujarat, India

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Poojadevi Sharma B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad — 380 054, Gujarat, India

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Nancy Shah National Institute of Pharmaceutical Education and Research (NIPER) — Ahmedabad, c/o B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad — 380 054, Gujarat, India

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Sonal Sharma B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad — 380 054, Gujarat, India

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Neeta Shrivastava B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad — 380 054, Gujarat, India

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Pages:
203–208
Online Publication Date:
Jun 2016
Publication Date:
01 Jun 2016
Article Category:
Research Article
DOI:
https://doi.org/10.1556/1006.2016.29.3.6
Keywords:
Bacopa monnieri ; Bacoside A; Chemodiversity; Ecogeographical variations; Genetic diversity; High-performance thin-layer chromatography
Restricted access

Bacopa monnieri (L.) Pennell, commonly known as Brahmi, is an important medicinal plant of the Ayurvedic System of Medicine and is categorized as Medhya Rasayana, used for boosting memory. Bacoside A and B (saponins) are major bioactive compounds of the plant responsible for memory enhancement. Consistent quality and quantity of the bioactive compounds are a must to produce highly efficacious herbal drugs. The phytochemical diversity due to ecogeographical variations affects the persistent therapeutic effect. In the present study, quantification of the major bioactive principle of B. monnieri, bacoside A, was performed in order to evaluate chemodiversity in the plants collected from different ecogeographical locations. The analysis of 75 accessions showed a wide range of significant variation in bacoside A content. Further, genetic diversity study was carried out between high- and low-yielding accessions to correlate the effect of the genetic composition on chemical diversity. The cluster analyses of amplified fragment length polymorphism (AFLP) data of high and low bacoside A producing plants using dendogram and principal coordinate analysis (PCoA) revealed no specific clustering. The genetic diversity parameters calculated also support less genetic differentiation between low- and high-yielding accessions. The results clearly indicate that there is a prevalence of agroclimatic conditions on differential bacoside A accumulation in B. monnieri. The study will help to produce quality plant material to be used as phytomedicine.

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Cover JPC - Journal of Planar Chromatography - Modern TLC
JPC - Journal of Planar Chromatography - Modern TLC
Print ISSN:
0933-4173
Online ISSN:
1789-0993

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 6
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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