A study on the effect of oxidizing or reducing agents on the stability testing of piroxicam, tenoxicam, meloxicam, and isoxicam was performed. Detection of the formed oxidation and/or degradation products after reaction with factors such as iodine, potassium manganate( VII), hydrogen peroxide, and ascorbic acid was conducted by thin-layer chromatography (TLC)—densitometry technique. The reacting mixtures were also exposed to increasing temperatures. The chromatographic profiles showed the formation of several new peaks for all oxicams due to the presence of a number of degradation products formed in the presence of analyzed redox agents. The calculated kinetic parameters have confirmed the greatest stability of meloxicam and piroxicam and the smallest stability of isoxicam in the analyzed conditions. In the case of all the analyzed drugs, principal component analysis identified temperature as the main factor responsible for the speed of degradation and the shape of degradation profile.
D.Demertzi-Kovala, J. Organomet. Chem.691 (2006) 1767–1774.
D.Demertzi-Kovala, J. Organomet. Chem.691 (2006) 1767–1774.)| false