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  • 1 Maria Curie-Skłodowska University, Lublin, Poland
  • 2 Vexler and Baldin Laboratory of High Energy Physics, Dubna, Russia
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As it was shown in earlier experiments, magnetic field can influence various processes taking part in nature. One of them might be the permeation of chemical compounds across biological membranes. An excellent tool for investigations on that subject is chromatography. Basing on retention measurements performed using reversed-phase thin-layer chromatography (RP-TLC) and micellar liquid chromatography—thin-layer chromatography (MLC—TLC), descriptors of lipophilicity were calculated for the group of 1,2,4-triazole derivatives. The experiments were performed in moderate (≈0.4 T) magnetic field and simultaneously outside it. The analysis of the obtained data showed that the presence of an external static magnetic field can alternate the obtained descriptor values which allows to assume that the ability of passive permeation of the investigated substances across cellular membrane also changes. The intensity of changes depends on the structure of the chromatographed substance and the lipophilicity measurement method.

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