Chemical ultraviolet (UV) filters and preservatives used currently in sunscreen preparations are compounds of diverse structures, and the safety of their application depends on their inability to penetrate the skin and other barriers present in the human body. However, at least some of these chemicals meet the general requirements of the good blood—brain barrier (BBB) permeability described in the literature sources. The objective of this study was to examine the behavior of selected cosmetic raw materials (UV filters and preservatives) towards the BBB on the basis of the BBB permeability models developed in our earlier study, based on easily accessible RP-18 thin-layer chromatographic data and calculated molecular descriptors. The computed BBB permeability parameters B1 and B2 correlate with the chromatographic data (RF, RF/PSA) and calculated physicochemical descriptors usually associated with the BBB permeation (HA, Sa, DM, log D). The relationships between these values were developed by stepwise multiple regression analysis, validated, and found to explain 93–96% of the total variance. The models of the BBB permeation based on classification functions obtained previously from discriminant function analysis were used to assign the studied compounds to the groups of good (CNS+) or poor (CNS−) blood—brain barrier permeability, suggesting the inability of the majority of these compounds to cross the BBB. The universal character of BBB permeability models developed earlier was confirmed.