Direct enantioseparation of (±)-terbutaline has been achieved by ligand-exchange thin-layer chromatography. Enantiomerically pure L-amino acids (namely, L-tryptophan, L-phenyl alanine, and L-histidine) and Cu(II) acetate were used for the preparation of ligand- exchange reagents. Three different approaches were adopted for impregnating the plate with ligand-exchange reagents. The solvent system MeCN–CH2Cl2–MeOH–H2O, in different proportions, was found to be successful for enantioseparation. The results obtained with all the approaches have been compared. The effect of the concentration of Cu(II) acetate and a chiral selector has also been investigated. The spots were located in an iodine chamber.
V.A.Davankov, S.V.Rogozhin, J. Chromatogr.60 (1971) 280–283.
V.A.Davankov, S.V.Rogozhin, J. Chromatogr.60 (1971) 280–283.)| false