View More View Less
  • 1 Indian Institute of Technology Roorkee, Roorkee 247667, India
  • | 2 Maharishi Markandeshwar University, Mullana, Ambala 133207, India
Restricted access

The scientific development in the area of enantioseparation during the last few decades has centered on the production of new chiral stationary phases (CSPs) and new chiral derivatizing reagents (CDRs) for use in liquid chromatography, and in particular high-performance liquid chromatography (HPLC) only. Both CSPs and CDRs have several limitations which, in general, are ignored. Little attention has been paid to thin-layer chromatography (TLC) despite its many advantages compared to HPLC in pharmaceutical and drug analysis and the areas of natural products chemistry and organic synthesis, particularly enantioselective synthesis in purification of the product prior to establishing enantiomeric ratio by different method(s). TLC provides a rapid, easy, aff ordable, and simple approach in all these situations. The demonstrated capability and effi- ciency of TLC in direct resolution of the racemate clearly establish its superiority, and the methodology should allow its application in the resolution of several other racemates, irrespective of the functional group, in a very short time along with the recovery of native enantiomers (for further use).

  • [1]

    W. Vetter , in: J.L. Anderson, A. Berthod, V. Pino, A.M. Stalcup (eds.) Analytical Separation Science, Vol. 3, Wiley-VCH, Weinheim, 2015, pp. 849882.

    • Search Google Scholar
    • Export Citation
  • [2]

    L. Igwemezie , C.R. Kerr, K.M. McErlane, Xenobiotica 19 (1989) 677682.

  • [3]

    K.M. McErlane , L. Igwemezie, C.R. Kerr, J. Chromatogr. B 415 (1987) 335346.

  • [4]

    D.K. Kowk , L. Igwemezie, C.R. Kerr, K.M. McErlane, J. Chromatogr. B 661 (1994) 271280.

  • [5]

    H. Fieger , I.W. Wainer, Pharm. Biomed. Anal. 11 (1993) 11731179.

  • [6]

    M.H. Hyun , S.C. Han, B.H. Lipshutz, Y.J. Shin, W.J. Christopher, J. Chromatogr. A 959 (2002) 7583.

  • [7]

    W. Lee , J.Y. Jin, C.S. Baek, Microchem. J. 80 (2005) 213217.

  • [8]

    J.Y. Jin , W. Lee, M.H. Hyun, J. Liq. Chromatogr. Relat. Technol. 29 (2006) 841848.

  • [9]

    D.G. Freitag , R.T. Foster, R.T. Coutts, F.M. Pasutto, J. Chromatogr. B 616 (1993) 253259.

  • [10]

    O.P. Kleidernigg , W. Lindner, Chromatographia 44 (1997) 465472.

  • [11]

    R. Büschges , H. Linde, E. Mutschler, H.S. Lagguth, J. Chromatogr. A 725 (1996) 323334.

  • [12]

    R. Bhushan , S. Tanwar, J. Chromatogr. A 1216 (2009) 57695773.

  • [13]

    R. Bhushan , H. Brückner, J. Chromatogr. B 879 (2011) 31483161.

  • [14]

    R. Bhushan , S. Dixit, J. Chromatogr. A 1217 (2010) 76697676.

  • [15]

    A. Catalano , A. Carocci, Curr. Med. Chem. 23 (2016) 32273244.

  • [16]

    P. Malik , R. Bhushan, New J. Chem. 41 (2017) 1368113691.

  • [17]

    K. Günther , J. Chromatogr. A 448 (1988) 1130.

  • [18]

    R. Bhushan , J. Martens, Biomed. Chromatogr. 11 (1997) 280285.

  • [19]

    P. Malik , R. Bhushan, J. Chromatogr. Sci. 56 (2018) 9298.

For Submission Guideline click HERE

Manuscript Submission: JPC Manuscript Submission

Senior editors

Editor(s)-in-Chief: B. Spangenberg

Managing Editor: Kakuk Ágnes

Editorial Board

  • T.H. Dzido (Lublin, Poland)
  • Á. M. Móricz (Budapest, Hungary)
  • C.F. Poole (Detroit, MI, USA)
  • E. Reich (Muttenz, Switzerland)
  • B. Renger (Radolfzell, Germany)
  • I. Vovk (Ljubljana, Slovenia)

 

Advisory Board

  • E. BODOKI (Cluj-Napoca, Romania)
  • U. A. TH. BRINKMAN (Amsterdam, The Netherlands)
  • I. CHOMA (Lublin, Poland)
  • V. COMAN (Cluj-Napoca, Romania)
  • W. DAMMERTZ (Kressbronn, Germany)
  • K. FERENCZI-FODOR (Budapest, Hungary)
  • G. INDRAYANTO (Surabaya, Indonesia)
  • R. E. KAISER (Bad Dürkheim, Germany)
  • I. KLEBOVICH (Budapest, Hungary)
  • T. KOWALSKA (Katowice, Poland)
  • L. LEPRI (Florence, Italy)
  • E. MINCSOVICS (Budapest, Hungary)
  • D. NUROK (Indianapolis, IN, USA)
  • B. RENGER (Radolfzell, Germany)
  • J. K. RÓŻYŁO (Lublin, Poland)
  • J. SHERMA (Easton, PA, USA)
  • M. WAKSMUNDZKA-HAJNOS (Lublin, Poland)
  • D. WEDGE (Mississippi, USA)

A. Kakuk - Managing Editor, Akadémiai Kiadó
Address: P.O. Box 245. H-1519 Budapest, Hungary
Fax: +36 1 464 82 95
E-mail: jpc@akkrt.hu

Indexing and Abstracting Services:

  • Science Citation Index
  • Sci Search Research Alert
  • Chemistry Citation Index and Current Content/Physical
  • Chemical and Earth Sciences

 

Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Feb 2021 18 0 0
Mar 2021 11 0 0
Apr 2021 8 0 0
May 2021 10 0 0
Jun 2021 60 0 0
Jul 2021 9 0 0
Aug 2021 0 0 0