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  • 1 Department of Chemistry, Lovely Professional University, Phagwara 144411, Punjab, India
  • | 2 Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India
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Summary

Direct resolution of enantiomers of (RS)-ketorolac was achieved by thin-layer chromatography on silica gel plates using enantiomerically pure L-tryptophan, L-valine, L-methionine, and L-histidine as chiral additive in the stationary phase. The solvent system (acetonitrile, methanol water, and chloroform) with different ratios was successful in resolving the enantiomers. Spots were detected by use of iodine vapor. The detection limit was 0.4 µg mL−1 for each enantiomer of (RS)-ketorolac. The native enantiomers were isolated and characterized.

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
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1988
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