Authors:
Gábor Bognár II. sz. Sebészeti Klinika, Semmelweis Egyetem, 1125, Budapest, Kútvölgyi út 4.

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Gábor István II. sz. Sebészeti Klinika, Semmelweis Egyetem, 1125, Budapest, Kútvölgyi út 4.

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György Ledniczky II. sz. Sebészeti Klinika, Semmelweis Egyetem, 1125, Budapest, Kútvölgyi út 4.

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Pál Ondrejka II. sz. Sebészeti Klinika, Semmelweis Egyetem, 1125, Budapest, Kútvölgyi út 4.

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Absztrakt

A humán papillomavírus (HPV) etiológiai szerepe számos laphámeredetű malignomában ismert. A colon laphámsejtes rákja (SCC) ritka betegség, etiológiája bizonytalan. Egy általunk operált SCC-eset kapcsán célunk volt kimutatni egy esetleges HPV-fertőzést. Egy 94 éves nőbeteget operáltunk passage-zavart okozó colon descendens tumor miatt. A szövettani vizsgálat SCC-t igazolt. Korábban kidolgozott módszerrel PCR- és Southern blot hybridisatiós technikával vizsgáltuk meg a daganatszövetet és az eltávolított nyirokcsomókat. Az eset kapcsán átnéztük az SCC-re vonatkozó irodalmat. A malignomákban leggyakrabban előforduló HPV-típusok (16, 18) közül a HPV-16 jelenlétét tudtuk igazolni a SCC-ben és a környező 9 nyirokcsomóból 4-ben. Ezek közül 2 metastaticus volt. Egy SCC-s betegnél sikerült HPV-16-fertőzöttséget kimutatni, a primer tumorból és a metastaticus nyirokcsomók mellett további környező nyirokcsomókból. Ilyen tanulmányt tudomásunk szerint még senki nem közölt.

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Magyar Sebészet
Language Hungarian
Size A4
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Founder Magyar Sebész Társaság -- Hungarian Surgical Society
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ISSN 0025-0295 (Print)
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