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  • 1 II. sz. Sebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar, 1125, Budapest, Kútvölgyi út 4.
  • | 2 Sebészeti Klinika, Albert Ludwig Tudományegyetem, Freiburg
  • | 3 III. sz. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest
  • | 4 Patológiai Intézet, Albert Ludwig Tudományegyetem, Freiburg
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Bevezetés: A tumorok vascularisatiójának és proliferatiójának prognosztikai szerepéről eltérő eredmények láttak napvilágot. A végbélrák prognosztikájában a májmetastasis jelenléte vagy megjelenése meghatározó szereppel bír. Munkánk célja a fenti prognosztikai faktorok vizsgálata és elemzése volt. Beteganyag és módszer: 37 végbélrákos betegnél végeztünk vizsgálatokat, akik preoperatív radioterápián, resectión és adjuváns kemoterápián estek át. A májmetastasisok közül 17 szinkrón volt, a többi öt éven belül került felismerésre. Immunhisztokémiai eljárással (CD34 és MIB-1) határoztuk meg a rectumtumor vascularisatióját (microvessel density: MVD) és a proliferatiós indexet (PI). Az eredményeket összevetettük a klinikopatológiai leletekkel és a betegek utánkövetési eredményeivel. Eredmények: A túlélésre a metastasis megjelenése volt a legjelentősebb befolyással. A pN státusz és a MVD ugyancsak szignifikánsan prognosztikus volt a betegségmentes és az 5 éves túlélésre egyaránt. A magasabb PI csak alacsony tumorvascularisatio mellett mutatott kedvező prognosztikai értéket. Összefoglalás: Az általunk vizsgált májmetastasist adó rectalis adenocarcinomák esetében a metastasisok megjelenéséig eltelt idő, a nyirokcsomók érintettsége (pN) és a tumor vascularisatiója bizonyult független kedvezőtlen prognosztikai faktornak.

  • 1. M Herlyn WH Clark U Rodeck ML Mancianti J Jambrosic H Koprowski 1987 Biology of tumor progression in human melanocytes Lab Invest 65 461 74.

    • Search Google Scholar
    • Export Citation
  • 2. P Macchiarini G Fontanini MJ Hardin F Squartini GA Angeletti 1992 Relation of vascularisation to metastasis of non-small-cell lung cancer Lancet 340 145 6.

    • Search Google Scholar
    • Export Citation
  • 3. TV Weidner PR Caroll J Flax W Blumenfeld J Folkman 1993 Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma Am J Pathol 143 401 9.

    • Search Google Scholar
    • Export Citation
  • 4. ML Mlynek D van Beuningen LD Leder C Streffer 1985 Measurements of the grade of vascularisation in histological tumor tissue sections Br J Cancer 52 945 8.

    • Search Google Scholar
    • Export Citation
  • 5. R Porschen CH Lange A Kriegel B Lohe F Borchard 1989 Critical evaluation of histochemical and immunohistochemical methods for the demonstration of vascular supply in rectal and oesophageal cancer Br J Cancer 60 299 302.

    • Search Google Scholar
    • Export Citation
  • 6. L Roncucci M Pedroni A Scalmanti ML Bormioli R Sassateli R Fanter et al.1992 Cell kinetics evaluation of colorectal tumour after in vivo administration of bromodeoxyuridine Int J Cancer 52 856 61.

    • Search Google Scholar
    • Export Citation
  • 7. TJ Saclarides NJ Speziale E Drab D Szeluga DB Rubin 1994 Tumor angiogenesis and rectal carcinoma Dis Colon Rectum 37 921 6.

  • 8. PB Vermeulen D Verhoeven H Fierens G Hubens G Goovaerts et al.1995 Microquantification in primary colorectal carcinoma: an immunohistochemical study Br J Cancer 71 340 3.

    • Search Google Scholar
    • Export Citation
  • 9. L Holmgren MS O'Reilly J Folkman 1995 Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression Nature Med 1 149 53.

    • Search Google Scholar
    • Export Citation
  • 10. C Hoang M Polivka P Valleur P Hautefeuille J Németh A Galian 1989 Immunohistochemical detection of proliferating cells in colorectal carcinomas and adenomas with the monoclonal antibody Ki-67 Virchows Arch 414 423 8.

    • Search Google Scholar
    • Export Citation
  • 11. PG Johnston MJ O'Brien PA Dervan DN Carney 1989 Immunohistochemival analysis of cell kinetic parameters in colonic adenocarcinomas, adenomas and normal mucosa Hum Pathol 20 696 700.

    • Search Google Scholar
    • Export Citation
  • 12. R Porschen A Kriegel C Langen S Classen M Hilse B Lohe KJ Hengels et al.1991 Assessment of proliferative activity in carcinomas of the human alimentary tract by Ki-67 immunostaining Int J Cancer 47 686 91.

    • Search Google Scholar
    • Export Citation
  • 13. NA Shepard PL Richman J England 1988 Ki-67 derived proliferative activity in colorectal adenocarcinoma with prognostic correlations J Pathol 155 213 9.

    • Search Google Scholar
    • Export Citation
  • 14. SK Banerjee DK Sarkar AP Weston A De DR Campbell 1997 Over expression of vascular endothelial growth factor and its receptor during the development of estrogen-induced rat pituitary tumors may mediate estrogen-initiated tumor angiogenesis Carcinogenesis 18 1155 61.

    • Search Google Scholar
    • Export Citation
  • 15. CH Blood BR Zetter 1990 Tumor interactions with the vasculature: angiogenesis and tumor metastasis Biochem Biophys Acta 1032 89 118.

    • Search Google Scholar
    • Export Citation
  • 16. J Folkman 1990 What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82 4 6.

  • 17. J Folkman K Watson D Lngber D Hanahan 1989 Introduction of angiogenesis during the transition from hyperplasia to neoplasia Nature 339 58 61.

    • Search Google Scholar
    • Export Citation
  • 18. TJ Saclarides 1997 Angiogenesis in colorectal cancer Surg Clin North Am 77 253 60.

  • 19. S Tomisaki S Ohno Y Lchiyoshi H Kuwano Y Maehara K Sugimachi 1996 Microvessel quantification and its possible relation with liver metastasis in colorectal cancer Cancer 77 1722 8.

    • Search Google Scholar
    • Export Citation
  • 20. N Weidner J Folkman F Pozza P Bevilacqua EN Allred DH Moore et al.1992 Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma J Natl Cancer Inst 84 1875 87.

    • Search Google Scholar
    • Export Citation
  • 21. ER Horak R Leek N Klenk S Lejeune K Smith N Stuart et al.1992 Angiogenesis, assessed by platalet/endothelial cell adhesion molecule antibodies, as indicator of node metastasis and survival in breast cancer Lancet 340 1120 4.

    • Search Google Scholar
    • Export Citation
  • 22. N Weidner JP Semple WR Welch J Folkman 1991 Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma N Engl J Med 324 1 8.

    • Search Google Scholar
    • Export Citation
  • 23. P Bossi G Viale AKC Lee RM Alfano G Coggi S Bosari 1995 Angiogenesis in colorectal tumors: microvessel quantification in adenomas and carcinomas with clinicopathological correlation Cancer Res 55 5049 53.

    • Search Google Scholar
    • Export Citation
  • 24. T Sternfeld HD Foss M Kruschewski N Runkel 1999 The prognostic significance of tumor vascularisation in patients with localized colorectal cancer Int J Colorectal Dis 14 272 6.

    • Search Google Scholar
    • Export Citation
  • 25. N Pietra L Sarli P Caruana A Cabras R Costi S Gobbi C Bordi A Peracchia 2000 Is tumor angiogenesis a prognostic factor in patients with colorectal cancer and no involved nodes? Eur J Surg 166 552 6.

    • Search Google Scholar
    • Export Citation
  • 26. GW Cockerill JR Gamble MA Vadas 1995 Angiogenesis: models and modulators Int Rev Cytol 159 113 60.

  • 27. AR Gagliardi B Hennig DC Colllins 1996 Antiestrogen inhibit endothelial cell growth stimulated by angiogenic growth factors Anticancer Res 16 1101 6.

    • Search Google Scholar
    • Export Citation
  • 28. A Marinho R Soares J Ferro M Lacerda FC Schmitt 1997 Angiogenesis in breast cancer is related to age but not to other prognostic parameters Pathol Res Pact 193 267 73.

    • Search Google Scholar
    • Export Citation
  • 29. AR Hanauske 1996 The development of new chemotherapeutic agents Anticancer Drugs 7 29 32.

  • 30. HO Wintzer I Zipfel J Schulte-Mönting U Hellerich S von Kleist 1991 Ki-67 immunostaining in human breast tumors and its relationship to prognosis Cancer 67 421 8.

    • Search Google Scholar
    • Export Citation
  • 31. A Janson XF Sun 1997 Ki-67 expression in relation to clinicopathological variables and prognosis in colorectal adenocarcinomas APMIS 105 730 4.

    • Search Google Scholar
    • Export Citation
  • 32. A D'Errico S Garbisa LA Liotta V Castronovo WG Stetler-Stevenson et al.1991 Augmentation of type IV collagene, laminin receptor and Ki-67 proliferation antigen assossiated with human colon, gastric and breast carcinoma progression Mod Pathol 4 239 46.

    • Search Google Scholar
    • Export Citation
  • 33. R Palmquist A Öberg C Bergström J Rutegard B Zackrisson R Stenling 1998 Systematic heterogenety and prognostic significance of cell proliferation in colorectal cancer Br J Cancer 77 917 25.

    • Search Google Scholar
    • Export Citation
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Magyar Sebészet
Language Hungarian
Size B5
Year of
Foundation
1947
Publication
Programme
2021 Volume 74
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Sebész Társaság -- Hungarian Surgical Society
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Address
H-1082 Budapest, Hungary Üllői út 78.
Publisher Akadémiai Kiadó
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Address
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ISSN 0025-0295 (Print)
ISSN 1789-4301 (Online)

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