Authors:
György Ledniczky II. sz. Sebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar, 1125, Budapest, Kútvölgyi út 4.

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Gábor Bognár II. sz. Sebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar, 1125, Budapest, Kútvölgyi út 4.

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Bíborka Bereczky II. sz. Sebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar, 1125, Budapest, Kútvölgyi út 4.

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Loránd Barabás II. sz. Sebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar, 1125, Budapest, Kútvölgyi út 4.

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Pál Ondrejka II. sz. Sebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar, 1125, Budapest, Kútvölgyi út 4.

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Absztrakt

A pancreascarcinoma praecursorainak tartott intraepithelialis neoplasia (PanIN1–3) és az intraductalis papillaris mucinosus neoplasia (IPMN) hisztopatológiailag és morfológiailag igen heterogén entitás, konzekvens osztályozásuk a közelmútban valósult meg. Áttekintjük a praecancerosisok klinikopatológiai és molekuláris genetikai jellemzőit, melyek az irodalmi adatok szerint egybevágnak az intraepithelialis és intraductalis neoplasiák noninvazív, noninfiltratív viselkedésével, és részben magyarázhatják a pancreas carcinomákétól eltérő, kitűnő prognózisukat.

  • 1. DS Klimstra DS Longnecker 1994 K-ras mutations in pancreatic ductal proliferative lesions Am J Pathol 145 1547 50.

  • 2. RH Hruban K Takaori DS Klimstra NV Adsay J Albore-Saavedra AV Biankin SA Biankin et al.2004 An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal mucinous papillary neoplasms Am J Surg Pathol 28 8 977 87.

    • Search Google Scholar
    • Export Citation
  • 3. K Ohhasi Y Murakami T Takekoshi 1982 Four cases of mucous secreting pancreatic cancer Prog Diagn Endosc 20 348 51.

  • 4. F Sessa E Solcia C Capella et al.1994 Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erb-2 abnormalities in 26 patients Virch Arch 425 357 67.

    • Search Google Scholar
    • Export Citation
  • 5. Longnecker DS , Adler G, Hruban RH et al.: Intraductal papillary mucinous neoplasms of the pancreas. WHO Classification of Tumors of the Digestive System. 2000, 23740.

    • Search Google Scholar
    • Export Citation
  • 6. NV Adsay K Merati A Andrea 2002 The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 support the existence of two separate pathways of carcinogenesis Mod Pathol 15 1087 95.

    • Search Google Scholar
    • Export Citation
  • 7. D Hedly M Fiedlander I Taylor C Rugg E Musgrove 1983 Method for analysis of cellular DNA content of paraffin-embedded pathologic material using flow cytometry J Hystochem Cytochem 31 1333 5.

    • Search Google Scholar
    • Export Citation
  • 8. H Baisch W Gohde W hinder 1975 Analysis of PCP data to determine fraction of cells in various phases of the cell cycle Radiat Environ Biophys 12 31.

    • Search Google Scholar
    • Export Citation
  • 9. JL Cameron DV Crist JV Sitzmann 1991 Factors influencing survival after pancreatoduodenectomy for pancreatic cancer Am J Surg 161 120 5.

    • Search Google Scholar
    • Export Citation
  • 10. CJ Yeo RH Hruban SE Kern et al.1994 Adenocarcinoma of the pancreas: factors influencing outcome after pancreatoduodenectomy – the Johns Hopkins experience Canc Bull 46 505 10.

    • Search Google Scholar
    • Export Citation
  • 11. RH Hruban M Goggins JL Parsons et al.2000 Progression model for pancreatic cancer Clin Canc Res 6 2969 72.

  • 12. CJ Sherr 1996 Cancer cell cycles Science 274 1672 7.

  • 13. S Gansauge F Gansauge M Ramadani 1997 Overexpression of cyclin D1 in human pancreatic carcinoma associated with poor prognosis Cancer Res 57 1634 7.

    • Search Google Scholar
    • Export Citation
  • 14. AV Biankin JG Kench FP Dijkman SA Biankin SM Henshall 2003 Molecular pathogenesis of precursor lesions of pancreatic ductal adenocarcinoma Pathol 35 14 24.

    • Search Google Scholar
    • Export Citation
  • 15. RH Hruban CJ Yoe SE Kern 1996 Pancreatic cancer B Vogelstein KW Kinzler The Genetic Basis of Human Cancer McGraw-Hill London 603 13.

    • Search Google Scholar
    • Export Citation
  • 16. H Friess PO Berberat M Schilling J Kunz M Korc MW Buchler 1996 Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors J Mol Med 74 35 42.

    • Search Google Scholar
    • Export Citation
  • 17. RH Hruban ADM Van Mansfield JGA Offerhaus et al.1993 K-ras oncogene activation in adenocarcinoma of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction and allele-specific oligonucleotide hybridization Am J Pathol 143 545 54.

    • Search Google Scholar
    • Export Citation
  • 18. E Rozenblum M Schutte M Goggins et al.1997 Tumor-suppressive pathways in pancreatic carcinoma Canc Res 57 1731 1.

  • 19. JD Day JA Digiuseppe C Yeo et al.1996 Immunohystochemical evaluation of HER/2neu expression in pancreatic adenocarcinoma and pancreatic intraepithelail neoplasms Hum Pathol 27 119 24.

    • Search Google Scholar
    • Export Citation
  • 20. RE Wilentz J Geradts R Maynard et al.1998 Inactivation of the pl6 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression Canc Res 58 4740 1.

    • Search Google Scholar
    • Export Citation
  • 21. AV Biankin JG Kench AL Morey et al.2001 Overexpression of p2lWAF1/CIP1 is an early event in the development of pancreatic intraepithelail neoplasia Canc Res 61 8830 7.

    • Search Google Scholar
    • Export Citation
  • 22. GE Kim HI Bae HU Park et al.2002 Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas Gastroent 123 1052 60.

    • Search Google Scholar
    • Export Citation
  • 23. MJ Swartz SK Batra GC Varshney et al.2002 MUC4 expression increases progressively in pancreatic intraepithelial neoplasia Am J Clin Pathol 117 791 6.

    • Search Google Scholar
    • Export Citation
  • 24. N Atkin R Kay 1979 Prognostic significance of modal DNA value and other factors in malignant tumors based on 1465 cases Br J Canc 40 210 21.

    • Search Google Scholar
    • Export Citation
  • 25. AR Weger AH Graf U Askensten et al.1987 Ploidy as prognostic determinant in pancreatic cancer Lancet 2 1031.

  • 26. G Schwab AR Weger R Pointner et al.1990 DNA content as prognostic factor in resected pancreatic carcinoma Dig Surg 7 8 12.

  • 27. H Joensuu KA Alanen PJ Klemi R Aine 1990 Evidence for false aneuploid peaks in flow cytometric analysis of paraffin-embedded tissue Cytometry 11 431 7.

    • Search Google Scholar
    • Export Citation
  • 28. S Kozuka R Sassa T Taki et al.1979 Relation of pancreatic duct hyperplasia to cracinoma Cancer 43 1418 28.

  • 29. K Nishihara T Fukada M Tsuneyoshi et al.1993 Intraductal papillary neoplasms of the pancreas Cancer 72 689 96.

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Magyar Sebészet
Language Hungarian
Size A4
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1947
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Founder Magyar Sebész Társaság -- Hungarian Surgical Society
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ISSN 0025-0295 (Print)
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