Author:
Author:
Eiji Kobayashi
eijikoba@jikei.ac.jp
https://orcid.org/0000-0001-8617-3778
Eiji Kobayashi
Department of Kidney Regenerative Medicine, Industry-Academia Collaborative Department, The Jikei University School of Medicine, Tokyo , Japan
Search for other papers by Eiji Kobayashi in
Current site
Google Scholar
PubMed
Search for other papers by Eiji Kobayashi in
Current site
Google Scholar
PubMed
Abstract
Small intestinal transplantation has emerged as an essential treatment for intestinal failure, but its relatively high graft rejection rate and mortality rate when compared to those of other transplanted organs has led to difficulties in post-transplantation treatment management. The recently-developed technique of creating organoids from somatic stem cells has created a challenging opportunity to develop a treatment that involves the creation of a substitute small intestine using autologous cells instead of transplanting another individual's small intestines. The remaining partial large intestine is then used as a segmental graft, and autologous small intestinal organoid transplantation is conducted on its epithelium in order to create a pedunculated hybrid graft. This is a new surgical technique for interposing with the original ileocecal region. The hybrid large intestine acquires both the lymphatic vessels that are involved in nutrient absorption and the original peristaltic function of the large intestine.
This lecture touches upon the history of the development of organoid medicine, after which an introduction is provided of the revolutionary surgical technique in which a functional small intestine is created by regenerating autologous cells.
The content here was introduced in a special lecture (online) at the 29th Congress of the Experimental Surgical Session of the Hungarian Surgical Society (Host: Dr. Norbert Nemeth, 9/9/2022, Budapest).
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Pironi L, Steiger E, Joly F, Jeppesen PB, Wanten G, Sasdelli AS, et al. Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: an international multicenter survey. Clin Nutr ESPEN 2021 Oct; 45: 433–41. https://doi.org/10.1016/j.clnesp.2021.07.004. Epub 2021 Jul 28.
-
2.
Kobayashi E. Organ fabrication: progress and hurdles to overcome. Current Transplantation Reports https://doi.org/10.1007/s40472-022-00372-3.
-
3.
Caleb I, Erlitz L, Telek V, Vecsernyés M, Sétáló G Jr, Hardi P, et al. Characterizing autophagy in the cold ischemic injury of small bowel grafts: evidence from Rat Jejunum. Metabolites 2021 Jun 17; 11(6): 396. https://doi.org/10.3390/metabo11060396.
-
4.
Kobayashi E, Enosawa S. Liver bud transplantation in rats. Magy Seb 2018 Dec; 71(4): 163–9. https://doi.org/10.1556/1046.71.2018.4.3.
-
5.
Yanagi Y, Nakayama K, Taguchi T, Enosawa S, Tamura T, Yoshimaru K, et al. In vivo and ex vivo methods of growing a liver bud through tissue connection. Sci Rep 2017 Oct 26; 7(1): 14085. https://doi.org/10.1038/s41598-017-14542-2.
-
6.
Kawai Y, Tohyama S, Arai K, Tamura T, Soma Y, Fukuda K, et al. Scaffold-free tubular engineered heart tissue from human induced pluripotent stem cells using bio-3D printing technology in vivo. Front Cardiovasc Med 2022 Jan 20; 8: 806215. https://doi.org/10.3389/fcvm.2021.806215. eCollection 2021.
-
7.
Saito Y, Matsumoto N, Yamanaka S, Yokoo T, Kobayashi E. Beneficial impact of interspecies chimeric renal organoids against a xenogeneic immune response. Front Immunol 2022 Feb 15; 13: 848433. https://doi.org/10.3389/fimmu.2022.848433. eCollection 2022.
-
8.
Sugimoto S, Kobayashi E, Fujii M, Ohta Y, Arai K, Matano M, et al. An organoid-based organ-repurposing approach to treat short bowel syndrome. Nature 2021 Apr; 592(7852): 99–104. https://doi.org/10.1038/s41586-021-03247-2. Epub 2021 Feb 24.
-
9.
Wilson HV. A New method by which sponges may be artificially reared. Science 1907 Jun 7; 25(649): 912–15. https://doi.org/10.1126/science.25.649.912.
-
10.
Moscona A. The development in vitro of chimeric aggregates of dissociated embryonic chick and mouse cells. Proc Natl Acad Sci U S A 1957 Jan 15; 43(1): 184–94. https://doi.org/10.1073/pnas.43.1.184.
-
11.
Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998 Nov 6; 282(5391): 1145–7. https://doi.org/10.1126/science.282.5391.1145.
-
12.
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007 Nov 30; 131(5): 861–72. https://doi.org/10.1016/j.cell.2007.11.019.
-
13.
Takebe T, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 2013 Jul 25; 499(7459): 481–4. https://doi.org/10.1038/nature12271. Epub 2013 Jul 3.
-
14.
Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, Ferguson C, et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 2015 Oct 22; 526(7574): 564–8. https://doi.org/10.1038/nature15695. Epub 2015 Oct 7.
-
15.
Wu H, Uchimura K, Donnelly EL, Kirita Y, Morris SA, Humphreys BD. Comparative analysis and refinement of human PSC-derived kidney organoid differentiation with single-cell transcriptomics. Cell Stem Cell 2018 Dec 6; 23(6): 869–81.e8. https://doi.org/10.1016/j.stem.2018.10.010. Epub 2018 Nov 15.
-
16.
Combes AN, Zappia L, Er PX, Oshlack A, Little MH. Single-cell analysis reveals congruence between kidney organoids and human fetal kidney. Genome Med 2019 Jan 23; 11(1): 3. https://doi.org/10.1186/s13073-019-0615-0.
-
17.
Fernandes MA, Usatin D, Allen IE, Rhee S, Vu L. Improved enteral tolerance following step procedure: systematic literature review and meta-analysis. Pediatr Surg Int 2016 Oct; 32(10): 921–6. https://doi.org/10.1007/s00383-016-3927-9. Epub 2016 Jul 26.
-
18.
Sasaki H, Iwai S, Yokoo T, Kobayashi E. Transplantation of vulnerable renal organoids by use of a novel laparoscopic device in pigs. Transpl Direct 2021 Oct 22; 7(11): e777. https://doi.org/10.1097/TXD.0000000000001206. eCollection 2021 Nov.
Please, download the file from HERE
Petz Aladár County Teaching Hospital, Surgery
Vasvári Pál út 2. H-9024 Győr, Hungary
Phone: +36 96 503 320 --- Fax: +36 96 507 936
E-mail: olaha@petz.gyor.hu
Indexing and Abstracting Services:
- Index Medicus
- PubMed Central
- CABELLS Journalytics
| Magyar Sebészet | |
|---|---|
| Publication Model | Hybrid |
| Submission Fee | none |
| Article Processing Charge | 900 EUR/article |
| Printed Color Illustrations | 40 EUR (or 10 000 HUF) + VAT / piece |
| Regional discounts on country of the funding agency | World Bank Lower-middle-income economies: 50% World Bank Low-income economies: 100% |
| Further Discounts | Editorial Board / Advisory Board members: 50% Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100% |
| Subscription fee 2025 | Online subsscription: 332 EUR / 380 USD Print + online subscription: 380 EUR / 452 USD |
| Subscription Information |
Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content. |
| Purchase per Title | Individual articles are sold on the displayed price. |
| Magyar Sebészet | |
|---|---|
| Language | Hungarian |
| Size | A4 |
| Year of Foundation |
1947 |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Magyar Sebész Társaság -- Hungarian Surgical Society |
| Founder's Address |
H-1082 Budapest, Hungary Üllői út 78. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 0025-0295 (Print) |
| ISSN | 1789-4301 (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Mar 2024 | 116 | 0 | 0 |
| Apr 2024 | 86 | 1 | 1 |
| May 2024 | 52 | 0 | 0 |
| Jun 2024 | 98 | 1 | 2 |
| Jul 2024 | 52 | 0 | 0 |
| Aug 2024 | 86 | 3 | 4 |
| Sep 2024 | 18 | 0 | 0 |
Author:
Authors:
, , , , , , and
Kedvezőbb műtéti eredmények „onlay” hálóval, mint „sublay” helyzetben beültetettel
Varrattal, illetve hálóbeültetéssel történő hasfal-rekonstrukció prospektív, randomizált, multicentrikus vizsgálata – ötéves utánkövetés eredményei
Kedvezőbb műtéti eredmények „onlay” hálóval, mint „sublay” helyzetben beültetettel
Varrattal, illetve hálóbeültetéssel történő hasfal-rekonstrukció prospektív, randomizált, multicentrikus vizsgálata – ötéves utánkövetés eredményei
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Powered by PubFactory