99mTc—Sulphur colloid: A freeze-dried, single-step kit for liver imaging

A. Al-Hilli; N. Agha; I. Al-Jumaili; H. Al-Azzawi; M. Al-Hissoni; M. Jassim

doi:10.1007/bf02163209

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 104: Issue 5

^99mTc—Sulphur colloid: A freeze-dried, single-step kit for liver imaging

Authors:

A. Al-Hilli

A. Al-Hilli Nuclear Research Centre Radioisotope Production Department Tuwaitha Baghdad Iraq

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N. Agha

N. Agha Nuclear Research Centre Radioisotope Production Department Tuwaitha Baghdad Iraq

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I. Al-Jumaili

I. Al-Jumaili Nuclear Research Centre Radioisotope Production Department Tuwaitha Baghdad Iraq

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H. Al-Azzawi

H. Al-Azzawi Nuclear Research Centre Radioisotope Production Department Tuwaitha Baghdad Iraq

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M. Al-Hissoni

M. Al-Hissoni Ibin Al-Nafees Hospital for Cardiovascular Diseases Department of Nuclear Medicine Baghdad Iraq

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M. Jassim

M. Jassim Ibin Al-Nafees Hospital for Cardiovascular Diseases Department of Nuclear Medicine Baghdad Iraq

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Pages:: 273–283

Online Publication Date:: 27 Sep 2005

Publication Date:: 17 Apr 1986

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02163209

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Abstract

The formulation of a freeze-dried sulphide colloid kit, to be directly labelled with technetium is based on the preparation of tin/II/ sulphide precolloid, stabilized with carboxy methyl cellulose. The formation kinetics of the labelled colloid assessed by GCS-method showing a fast reduction of^99mTc-pertechnetate, forming reduced^99mTc-colloid with subsequent build-up of the labelled sulphur colloid. This is assumed to be due to the formation of^99mTc/V/ to be bound to sulphide precolloid of the kit. The blood clearance data of the labelled colloid in rabbits showed two exponential disappearance phases of radioactivity from blood with biological half times of 3 and 67 min. The results of organ distribution in mice show that more than 85% of the administered activity is accumulated in the liver indicating a high colloidal yield of optimal particle size. The dynamic studies of the labelled colloid achieved in normal subjects using gamma camera indicate a rapid blood clearance and high liver uptake with low surrounding tissue background.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)