Authors:
Y. Shafiq Baghdad and the Ibn Al-Nafis Cardiovascular Teaching Hospital Radioisotopes Production Department, Nuclear Research Centre P. O. Box 765 Baghdad Iraq)

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M. Al-janabi Baghdad and the Ibn Al-Nafis Cardiovascular Teaching Hospital Radioisotopes Production Department, Nuclear Research Centre P. O. Box 765 Baghdad Iraq)

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M. Abdel-Azeez Baghdad and the Ibn Al-Nafis Cardiovascular Teaching Hospital Radioisotopes Production Department, Nuclear Research Centre P. O. Box 765 Baghdad Iraq)

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M. Al-Hissoni Baghdad and the Ibn Al-Nafis Cardiovascular Teaching Hospital Radioisotopes Production Department, Nuclear Research Centre P. O. Box 765 Baghdad Iraq)

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M. Jassim Baghdad and the Ibn Al-Nafis Cardiovascular Teaching Hospital Radioisotopes Production Department, Nuclear Research Centre P. O. Box 765 Baghdad Iraq)

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Abstract  

Correlation between the in vivo distribution and the chemical formulation of99mTc-PYP complex has been studied. We chose mice to evaluate in vivo biodistribution and gel chromatography column scanning technique for radiochemical analysis. The influence of the pH, Sn(II), pyrophosphate concentration and molar ratios of Sn: PYP on the labelling of pyp with99mTc has been investigated in vitro and in vivo. The reaction between99mTc and Sn-PYP was complete within a few minutes. The stability studies were evaluated against dilution. Induced myocardial infarction was evaluated in rats. The clinical evaluation showed excellent definition of sternum and ribs with little blood background activity with normal subjects. Discrete localization of abnormally high activity was shown in the site of recent infarction of the left ventricular myocardium.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)