An epithermal energy neutron irradiation facility has been used to perform instrumental activation analysis for iodine, silicon, nickel, zirconium, uranium and thorium. The facility, which is adjacent to the fuel of the University of Virginia 2.0 MW pool reactor, consists of a dry sample region surrounded by a fixed cadmium shield. A boron nitride capsule can be used to hold the sample in the cadmium facility to further enhance the reduction of thermal neutron activation. The neutron fluence rate is 2.2×1016 n·m–2·s–1 for fission spectrum energy neutrons (measured with Ni(n,p)Co) and 8.2·1015 n·m–2·s–1 for resonance energy neutrons (measured with gold).Iodine has been measured at concentrations as low as 0.1 mg/kg with 3% counting statistics in powdered infant formula and 0.15 mg/kg with 5% statistics in liquid infant formula. Silicon has been measured at concentrations of 0.2% in biological samples with counting statistics between 5 and 10% and in coal and soil at concentrations greater than 4% with better than 1% statistics. Nickel has been measured in coal and soil at the 20 mg/kg level and higher with 6% statistics. Zirconium has been determined at 600 mg/kg and greater in ceramics with counting errors less than 3%. Uranium and thorium have been measured at the 10 mg/kg level with 3% counting statistics.