2-Pentanoylfuran was synthesized by three different methods and the yield of each method was determined. The ketone was purified and 2-propanol was also purified from acetone. Their purities were measured by gas chromatography. Mixtures of 2-pentanoylfuran in 2-propanol with concentrations 1, 10–1, 10–2 M had been irradiated by60Co -rays at different doses. The percent amount and radiation yield of ketone lost were determined at different absorbed doses. The discussion was used to interpret the results obtained.