In this paper are presented the theoretical approaches and some considerations of the TE-role in biological processes of diseases development in HCM-specific diagnostic series (N, CCH, CU, AT and ACa) and the influence of the pathological alterations on the numerical changes of CE (contents of elements) and D (distribution coefficient) parameter values in the mentionend serier. The CE and D parameters for elements, Cr, Fe, Co, Zn, Sb and Sc are obtained by INAA of HCM and were verified and evaluated by statistical treatments in parts 1 and 2 of this communication. The following can be concluated by statistical treatments in parts 1 and 2 of this communication. The following can be concluded: — the CE parameters can still not be used as the absoloute measure of the pathological alterations in HCM-DS (insufficient knowledge of TE-role in living matter); — the D parameters could be used as the relative measure of pathological alterations in such DS, and — numerical changes of CE and D parameters in DS could be explained on the basis of biological/biochemical behaviour of the TE found in HCM-DS and on the possible variations of D parameters (as a function of CE parameters) for the cases: (1) CE
CE¨' and (2)CE
CE¨' presented in this paper.