Authors:
N. Nair Bhabha Atomic Research Centre Radiopharmaceuticals Division Trombay 400 085 Bombay (India)

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M. Pillai Bhabha Atomic Research Centre Radiopharmaceuticals Division Trombay 400 085 Bombay (India)

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R. Mani Bhabha Atomic Research Centre Radiopharmaceuticals Division Trombay 400 085 Bombay (India)

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S. Naik B. J. Wadia Hospital for Children and Institute of Child Health Parel 400 012 Bombay (India)

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M. Desai B. J. Wadia Hospital for Children and Institute of Child Health Parel 400 012 Bombay (India)

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P. Upadhye B. J. Wadia Hospital for Children and Institute of Child Health Parel 400 012 Bombay (India)

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M. Colaco B. J. Wadia Hospital for Children and Institute of Child Health Parel 400 012 Bombay (India)

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Abstract  

A single reagent radioimmunoassay for thyroxine in blood samples absorbed on filter paper for the mass screening of neonatal hypothyroidism is described. Blood samples were collected by pricking the heel of newborn babies (3 days old) and pressing Whatman 3 filter paper against the wound. 6 mm diameter blood spots were punched out at the time of assay and incubated with 0.4 ml of a preincubated antigen-antibody complex for six hours at 37 °C. 1 ml of 22% polyethylene glycol is used for the precipitation of antigen-antibody complex. The assay has a sensitivity of 2.2 ng/ml. 500 samples collected from newborns were analyzed in the assay and gave a mean of 117.6±31.9 ng/ml.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)