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  • 1 Fachbereich 14, Kernchemie-Philipps-Universität 3550 Marburg (FRG)
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Abstract  

The utilization of carrier-free ionic18F is a convenient method for studying the effects of very low extracellular fluoride concentrations on the metabolism of the cariogenic bacterium Streptococcus mutans. We have developed a method for the preparation of carrier-free aqueous solutions of ionic18F with high specific activity (about 707 Bq/ml). Fluoride distribution and fluoride binding experiments showed that submicromolar fluoride concentrations have already a negative effect on the metabolism of Streptococcus mutans.